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Microbial Biosensors01:17

Microbial Biosensors

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Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...
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Fluorescent Nanoparticles for the Measurement of Ion Concentration in Biological Systems
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Fluorescent Nanosensor for Indole-3-Propionic Acid Detection in Gut Health Monitoring.

Mervin Chun-Yi Ang1,2, Jonathan Wei Jie Lee3,4,5, Sayyid Mohaideen1

  • 1Disruptive & Sustainable Technologies for Agricultural Precision IRG, Singapore-MIT Alliance for Research and Technology, Singapore, Singapore.

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A novel fluorescent nanosensor detects indole-3-propionic acid (IPA), a gut inflammation biomarker. This system offers a faster, cost-effective alternative to mass spectrometry for gut health assessment.

Keywords:
Indole‐3‐propionic acidcarbon nanotubesconjugated polyelectrolytegut healthnanosensor

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Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Microbiology

Background:

  • Gut microbiota metabolizes tryptophan into indole-3-propionic acid (IPA).
  • IPA is an emerging biomarker for gut inflammation.
  • Current detection methods (mass spectrometry) are costly and time-consuming.

Purpose of the Study:

  • Develop a novel fluorescent nanosensor for IPA detection.
  • Enable rapid and cost-effective gut inflammation assessment.

Main Methods:

  • A dual-modal fluorescent nanosensor system using single-walled carbon nanotubes (SWNTs) and a cationic conjugated polyelectrolyte (CP3).
  • Utilized near-infrared (NIR) and visible emission channels for IPA detection.
  • Tested sensor functionality in a hydrogel for potential in vivo monitoring.

Main Results:

  • The nanosensor successfully detected IPA via quenching of both NIR and visible emission channels.
  • NIR channel allows detection in scattering tissues; visible channel enables point-of-care screening.
  • Significant differences in plasma IPA levels were observed between healthy individuals and those with ulcerative colitis or Crohn's disease.

Conclusions:

  • The developed fluorescent nanosensor system provides a promising tool for rapid gut health assessment.
  • Dual optical modalities offer versatility for different detection environments.
  • The sensor shows potential for continuous in vivo monitoring of IPA dynamics.