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Etripamil: First Approval.

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  • 1Springer Nature, Mairangi Bay, Private Bag 65901, Auckland, 0754, New Zealand. dru@adis.com.

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This summary is machine-generated.

Etripamil, an intranasal L-type calcium channel blocker, is now approved in the USA for treating symptomatic paroxysmal supraventricular tachycardia (PSVT) in adults. Further trials are underway for pediatric PSVT and atrial fibrillation with rapid ventricular rate.

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Area of Science:

  • Cardiovascular pharmacology
  • Drug development
  • Clinical trials

Background:

  • Symptomatic paroxysmal supraventricular tachycardia (PSVT) is a common cardiac arrhythmia.
  • Current treatments for PSVT may involve invasive procedures or have limitations.
  • Etripamil offers a novel intranasal approach for acute PSVT management.

Purpose of the Study:

  • To summarize the development milestones of etripamil.
  • To highlight the regulatory approval of etripamil for PSVT in adults.
  • To provide an overview of ongoing and future clinical investigations.

Main Methods:

  • Review of etripamil's development pathway.
  • Analysis of clinical trial data supporting PSVT indication.
  • Summary of regulatory submission and approval process.

Main Results:

  • Etripamil received US FDA approval on December 12, 2025, for acute symptomatic PSVT conversion to sinus rhythm.
  • The intranasal L-type calcium channel blocker demonstrated efficacy in adult PSVT patients.
  • Ongoing trials include Phase II for pediatric PSVT and Phase III for AF-RVR.

Conclusions:

  • Etripamil represents a significant advancement in the treatment of PSVT.
  • The intranasal CCB is poised to offer a convenient and effective option for patients.
  • Further research will expand the therapeutic applications of etripamil.