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Synthesis of Hypervalent Iodonium Alkynyl Triflates for the Application of Generating Cyanocarbenes
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Chemodivergent C-H Activation and C-C Coupling between Indoles and Alkyne-Tethered N-Cyanosulfonamides via
Jinlei Wang1, Panjie Hu1, Fen Wang2
1School of Chemistry and Chemical Engineering, Zhoukou Normal University, Zhoukou, Henan 466001, China.
Abstract:
Reported herein is Rh-catalyzed C-H activation of indoles en route to redox-neutral coupling with alkyne-tethered N-cyanosulfonamides. The transformation enables chemodivergent C-C coupling via selective migration of either the cyano or sulfonyl group in alkyne-tethered N-cyanosulfonamide, affording C-H olefination or heteroarylation, respectively. The reaction enables one-pot construction of multiple chemical bonds, exhibits broad functional group tolerance, and is accompanied by mechanistic studies.
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