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Revolutionizing Accelerated Percutaneous Initiation and Deployment of ECPR (RAPID ECPR): Single-Center Process and

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  • 1Department of Anesthesiology & Perioperative Medicine, Mayo Clinic, Rochester, MN; Department of Emergency Medicine, Mayo Clinic, Rochester, MN.

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|May 2, 2026
PubMed
Summary
This summary is machine-generated.

Implementing a structured extracorporeal cardiopulmonary resuscitation (ECPR) program improved neurologically intact survival rates. This streamlined approach, featuring rapid deployment and standardized processes, enhances patient outcomes following cardiac arrest.

Keywords:
ECPR Programextracorporeal cardiopulmonary resuscitation

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Area of Science:

  • Cardiology
  • Critical Care Medicine
  • Emergency Medicine

Background:

  • Extracorporeal cardiopulmonary resuscitation (ECPR) shows promise for neurologically intact survival, but rapid deployment is crucial.
  • Existing data suggest ECPR benefits are maximized within efficient extracorporeal membrane oxygenation (ECMO) systems.

Purpose of the Study:

  • To describe the implementation of a structured, single-center ECPR program.
  • To assess the impact of program enhancements on deployment efficiency and patient outcomes.

Main Methods:

  • A structured ECPR program was implemented at a tertiary and quaternary care academic medical center.
  • Key components included an ECPR emergency backpack, dedicated ECMO specialists, and a standardized ECPR checklist.
  • Clinical outcomes, including survival to hospital discharge with favorable neurologic status, were extracted from electronic medical records for 58 adult patients.

Main Results:

  • The overall rate of neurologically intact survival to hospital discharge was 34.5% among 58 ECPR patients.
  • Neurologically intact survival was 41.2% for out-of-hospital cardiac arrest and 31.7% for in-hospital cardiac arrest.

Conclusions:

  • A streamlined ECPR program focusing on rapid deployment, standardized processes, and dedicated personnel is feasible and impactful.
  • This model offers a reproducible framework for improving ECPR timeliness and neurologically intact survival rates.