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Electrical tracking-assisted cascaded microring biosensor for alpha-fetoprotein detection.

Jiamei Gu1, Yubo Xia2, Mingyu Li2

  • 1State Key Laboratory of Extreme Photonics and Instrumentation, Centre for Integrated Optoelectronics, College of Optical Science and Engineering, Zhejiang University, Hangzhou, 310027, China.

Biosensors & Bioelectronics
|May 3, 2026
PubMed
Summary
This summary is machine-generated.

This study introduces a novel optical biosensor for rapid alpha-fetoprotein (AFP) detection. The electrical tracing-assisted microring sensor offers a low-cost, sensitive solution for real-time health monitoring.

Keywords:
Alpha-fetoprotein detectionCascaded microringElectrical trackingIntensity interrogation

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Area of Science:

  • Biomedical Engineering
  • Optical Sensing
  • Biosensor Technology

Background:

  • Label-free optical sensors are vital for rapid health monitoring.
  • Existing intensity-based sensors have limitations in linear detection range.
  • Alpha-fetoprotein (AFP) is a key biomarker for certain cancers.

Purpose of the Study:

  • To develop an electrical tracing-assisted, intensity-detection-based cascaded microring biosensor.
  • To achieve real-time detection of alpha-fetoprotein (AFP) antigen-antibody binding.
  • To overcome the narrow linear detection range limitation of traditional intensity-based sensors.

Main Methods:

  • Fabrication of a cascaded microring biosensor with a functionalized sensing ring and a heated reference ring.
  • Utilizing an intensity-based detection setup with electrical tracing.
  • Evaluating sensor performance using refractive index measurements and AFP bio-sensing experiments.

Main Results:

  • The biosensor achieved a sensitivity of 9475.5 mW/RIU for refractive index sensing.
  • Demonstrated a linear detection range for AFP from 8 to 64 ng/mL.
  • Achieved a limit of detection (LOD) of 2.86 ng/mL for AFP, suitable for clinical assays.

Conclusions:

  • The electrical tracking-assisted cascaded microring biosensor provides a low-cost, sensitive, and real-time detection method.
  • This technology shows significant potential for detecting various biomarkers, including AFP, nucleic acids, and antigens.
  • The sensor overcomes limitations of traditional intensity-based detection, enhancing its applicability in health monitoring.