On the Prognostic Implications of Nuclear Atypia in Bethesda III Thyroid Nodules

Nuclear atypia has been proposed as a useful criterion for subclassifying thyroid nodules with atypia of undetermined significance (AUS), with potential implications for malignancy risk. In our analysis of nodules initially classified as AUS and subsequently confirmed as malignant, clinical outcomes were generally favourable and did not differ according to the presence of nuclear atypia. These findings suggest that while nuclear atypia may have diagnostic relevance, its prognostic impact may be limited.