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Updated: May 5, 2026

High-resolution Fiber-optic Microendoscopy for in situ Cellular Imaging
Published on: January 11, 2011
Ultra-low sampling fiber imaging system based on physical-enhanced IPSR
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Multimode fiber (MMF) imaging holds great potential in the field of minimally invasive endoscopy due to its ultra-fine outer diameter. However, the requirements for real-time monitoring and reduced phototoxicity force the system to operate at extremely low sampling rates, resulting in a severe loss of fidelity with traditional methods. Here, we introduce a physical-enhanced IPSR (Phys-IPSR) imaging framework. By implementing a deterministic front-end screening strategy to minimize mutual coherence and utilizing a dual-stage network to retrieve high-frequency features from extremely sparse data, Phys-IPSR significantly improves information encoding efficiency. At an extremely low sampling rate of only 0.77%, the system successfully achieves high-resolution reconstruction of 198 × 198 pixels, with an average PSNR of 36.46 dB and an SSIM of 0.8682, representing a fidelity improvement exceeding 20 dB over traditional compressed sensing methods. Furthermore, this framework demonstrates exceptional robustness within an axial defocus range of 30 mm (±15 mm), with a single-frame processing time of only 0.047 seconds. Phys-IPSR provides a design paradigm for high-fidelity fiber imaging under extreme sampling conditions, laying an important foundation for future clinically compatible endoscopic systems.
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