Related Experiment Video
Updated: May 5, 2026
03:47
Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application
Published on: September 27, 2024
1.6K
Grape Pomace Extract-Loaded Liposomes Enriched Cream Formulations for Skincare
Cristiana Radulescu1,2,3, Radu Lucian Olteanu1, Ramona-Daniela Pavaloiu4
1Faculty of Sciences and Arts, Valahia University of Targoviste, 13 Sinaia Alley, 130004 Targoviste, Romania.
Antioxidants (Basel, Switzerland)
|May 4, 2026
Summary
This study developed novel green cosmetic formulations using grape pomace extract and natural oils. These formulations offer skin hydration, anti-aging benefits, and antioxidant properties, with potential UV protection.
Area of Science:
- Dermatology and Cosmetic Science
- Natural Product Chemistry
- Formulation Science
Background:
- Growing consumer demand for 'green cosmetics' and natural anti-aging ingredients.
- Need for effective delivery systems for bioactive compounds from plant extracts.
- Grape pomace is a rich source of polyphenols with antioxidant and anti-aging potential.
Purpose of the Study:
- To develop and characterize novel dermatocosmetic formulations with multiple skin benefits.
- To incorporate grape pomace extract using liposome technology for enhanced delivery.
- To evaluate the bio-physico-chemical properties and antioxidant activity of the formulations.
Main Methods:
- Formulation of creams using natural oils, xanthan gum, vitamin E, and liposomes with grape pomace extract.
- Preparation of liposomes via thin-film hydration, ultrasonication, and extrusion.
- Comprehensive characterization including pH, stability, texture analysis, antioxidant capacity, and in vitro polyphenol release.
Main Results:
- Successful development of stable, homogeneous dermatocosmetic formulations with desirable sensory attributes.
- Demonstrated antioxidant activity and free radical scavenging capacity.
- Characterized in vitro release behavior of polyphenols from liposomes.
Conclusions:
- The developed formulations align with 'green cosmetics' principles, utilizing natural ingredients and advanced delivery systems.
- Liposome encapsulation enhances the incorporation and potential efficacy of grape pomace extract.
- The study resulted in a patent application for the novel dermatocosmetic formulations.
Related Concept Videos
01:24Lipid Absorption
3.9K
Dietary triglycerides from chyme in the duodenum are mixed with bile salts produced by the liver to emulsify fats. As a result, large droplets are broken down into smaller ones, increasing the surface area for enzymatic action. Once emulsified, pancreatic lipases hydrolyze the triglycerides into free fatty acids and monoglycerides.
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
3.9K
01:23Ophthalmic Drug Delivery Systems
283
Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
283
01:31Lipid-derived Compounds in the Human Body
5.5K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
5.5K
01:12Renewal of Skin Epidermal Stem Cells
2.4K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
2.4K
01:24Site-Targeted Drug Delivery Systems: Polymeric Carriers
160
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
160
00:59COP Coated Vesicles
12.6K
Membrane-enclosed structures called vesicles transport proteins and lipids across the cell. The vesicles derive their cargo from the plasma membrane, Golgi, ER, or endosome. Coated vesicles are spherical, protein-coated carriers with a 50–100 nm diameter that mediate bidirectional transport between the ER and the Golgi. The distribution of proteins between the ER and Golgi complex is dynamic and is maintained by different coated vesicles. Their formation is driven by the assembly of...
12.6K