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Subretinal Transplantation of Human Embryonic Stem Cell-Derived Retinal Tissue in a Feline Large Animal Model

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Intraocular Micro-LED Epiretinal Projection for Anterior Segment Blindness: Design and Large-Animal Feasibility

Bingao Zhang¹, Jiarui Yang², Hong Jiang^3,4

¹Key Laboratory for the Physics and Chemistry of Nanodevices, Institute of Physical Electronics, Department of Electronics, Peking University, Beijing 100871, China.

Bioengineering (Basel, Switzerland)

|May 4, 2026

Summary

A novel intraocular micro-light-emitting diode (Micro-LED) epiretinal microdisplay shows potential for restoring vision in anterior segment blindness. This device bypasses optical obstructions to stimulate photoreceptors, demonstrating preliminary neurophysiological evidence of visual pathway activation.

Keywords:

Micro-LED display anterior segment blindness artificial vision epiretinal implant intraocular projection transscleral implantation

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Area of Science:

Biomedical Engineering
Ophthalmology
Neuroscience

Background:

Anterior segment blindness, like dense corneal opacity, presents a significant challenge due to limited sight-restoring options.
Preserved retinal integrity in these cases necessitates alternative approaches to visual rehabilitation.

Purpose of the Study:

To describe and evaluate an intraocular micro-light-emitting diode (Micro-LED) epiretinal microdisplay.
To assess the potential of this device to restore vision by bypassing opaque anterior ocular structures and stimulating intact photoreceptors.

Main Methods:

Development of a color-capable VGA microdisplay (640 × 480 pixels) with a flexible cable and PDMS encapsulation for intraocular implantation.
Evaluation of a monochromatic (green) prototype in a single beagle eye via transscleral implantation.
Postoperative follow-up included slit-lamp examination, multimodal imaging, and assessment of flash-evoked visual evoked potentials (VEPs).

Main Results:

The Micro-LED display elicited flash-evoked VEPs, indicating preliminary neurophysiological evidence of visual pathway activation.
Short-term postoperative complications included transient hypotony and anterior segment inflammation.
Implant rotation and inferior retinal detachment were observed by day 7, indicating biomechanical limitations.

Conclusions:

The intraocular Micro-LED epiretinal microdisplay is a promising concept for addressing vision loss from anterior segment opacity.
Further engineering development is required to overcome biomechanical limitations and ensure chronic safety and functionality.
The platform may also serve as a modular light-delivery system for future retinal therapies like optogenetics.