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Ameliorative Effect of Valeric Acid Against Psychophysiological Chronic Unpredictable Stress
Bindu Kumari1, Gireesh Kumar Singh1, Gyan Prakash Modi2
1Department of Pharmacy, Central University of South Bihar, Gaya 824236, Bihar, India.
Biomedicines
|May 4, 2026
Summary
Valeric acid (VA), a postbiotic, effectively combats chronic unpredictable stress (CUS) in rats. It reversed stress-induced depression and normalized inflammatory and oxidative markers, showcasing significant anti-stress properties.
Area of Science:
- Neuroscience
- Pharmacology
- Biochemistry
Background:
- Chronic unpredictable stress (CUS) disrupts psychophysiological balance, leading to pathological and metabolic changes.
- Valeric acid (VA), a postbiotic, shows promise in mitigating stress-induced behavioral deficits in preclinical models.
Purpose of the Study:
- To evaluate the neuroprotective and biochemical effects of valeric acid against chronic unpredictable stress in a rodent model.
- To elucidate the underlying mechanisms of valeric acid's anti-stress action.
Main Methods:
- Establishment of a 14-day chronic unpredictable stress model in Wistar rats.
- Behavioral assessments including forced swim test, tail suspension test, and sexual behavior observation.
- Quantification of inflammatory cytokines (IL-6, TNF-α, IL-1β), plasma corticosterone, and oxidative stress markers.
Main Results:
- Valeric acid administration significantly reversed depression-like behaviors induced by CUS.
- Treatment with valeric acid normalized elevated proinflammatory cytokines and oxidative stress markers.
- The effects of valeric acid were comparable to the standard drug, Panax ginseng.
Conclusions:
- Valeric acid exhibits significant anti-stress effects by modulating behavioral and biochemical alterations associated with CUS.
- This study supports valeric acid as a potential therapeutic agent for stress-related disorders.
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