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Management Strategies for Congestive Heart Failure in Chronic Kidney Disease: Narrative Review
Pamela Soto-Santillan1, Andres Jacobo-Ruvalcaba2, Michael Eduard Wasung-de Lay1
1Department of Nephrology, Hospital Central Sur de Alta Especialidad, Petroleos Mexicanos, Mexico City 14140, Mexico.
Insights
Heart failure (HF) and chronic kidney disease (CKD) frequently coexist, increasing mortality. This review offers evidence-based strategies for managing HF in CKD patients to reduce hospitalizations and improve outcomes.
Area of Science:
- Cardiology
- Nephrology
- Internal Medicine
Background:
- Heart failure (HF) affects millions globally and often coexists with chronic kidney disease (CKD).
- Cardiovascular disease is a leading cause of death in CKD patients, exacerbating morbidity and mortality.
- Declining kidney function significantly increases the risk and worsens the prognosis of HF in CKD patients.
Purpose of the Study:
- To provide healthcare professionals with evidence-based strategies for identifying and managing the comorbidity of HF in CKD patients.
- To synthesize recent findings on risk stratification, diagnostic modalities, and individualized treatment for HF in CKD.
- To enhance volume management and optimize patient outcomes, particularly for those undergoing renal replacement therapy.
Main Methods:
- This narrative review synthesizes recent findings from medical literature.
- It addresses pathogenic mechanisms, diagnostic approaches, pharmacological treatments, and modifications in dialytic therapy.
- Focus is placed on evidence-based strategies for risk stratification and individualized management.
Main Results:
- The review highlights the complex interplay between HF and CKD, emphasizing the negative impact on patient prognosis.
- It underscores the importance of tailored management strategies, including volume control and optimized therapies.
- Specific attention is given to patients undergoing renal replacement therapy.
Conclusions:
- Effective management of HF in CKD patients is crucial for reducing hospitalizations and mortality.
- Individualized treatment approaches, considering pathogenic mechanisms and diagnostic findings, are essential.
- Optimizing care for CKD patients with HF can significantly improve quality of life and long-term outcomes.
Abstract:
Heart failure (HF) affects approximately 64 million people globally. HF often coexists with chronic kidney disease. HF may affect the heart during diastolic filling, systolic ejection, or both. Conventionally, HF is categorized by left ventricular ejection fraction (LVEF). One of the leading causes of death in chronic kidney disease (CKD) patients of cardiovascular origin increase hospitalizations and worsen quality of life by causing fluid and electrolyte overload. As kidney function declines, increases risk of development of HF in CKD, with a negative impact and worse prognosis in these patients. This narrative review provides healthcare professionals-including nephrologists, car-diologists, internists, and general practitioners-with evidence-based strategies to iden-tify and manage this complex comorbidity, aiming to reduce hospitalization and mor-tality in CKD patients. By synthesizing recent findings on risk stratification, diagnostic modalities, and individualized treatment-particularly for patients undergoing renal replacement therapy-clinicians can enhance volume management and optimize patient outcomes. Considering the increasing prevalence of chronic kidney disease and associated cardiovascular comorbidities, this review addresses pathogenic mechanisms, diagnostic approaches, pharmacological treatments, and dialytic therapy modifications.
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