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Single-Dose Creatine Reduces Sleep Deprivation-Induced Deterioration in Cognitive Performance.

Ali Gordji-Nejad1, Andreas Matusch1, Lea Hengstler1

  • 1Institute of Neuroscience and Medicine (INM-2), Molecular Organization of the Brain, Forschungszentrum Jülich, 52425 Jülich, Germany.

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Summary
This summary is machine-generated.

A lower dose of creatine monohydrate (0.2 g/kg) supplementation can mitigate cognitive decline during sleep deprivation. This study found improvements in logic, processing speed, and vigilance tests, with females showing greater benefits.

Keywords:
cognitive performancecreatinesleep deprivation

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Area of Science:

  • Neuroscience
  • Nutritional Science
  • Cognitive Psychology

Background:

  • Creatine supplementation is known for physiological benefits and positive effects on cognitive abilities.
  • Previous research demonstrated that a high dose (0.35 g/kg) of creatine impacts brain metabolism and cognitive performance during sleep deprivation.
  • The current study explores the cognitive effects of a lower creatine dose during sleep deprivation.

Purpose of the Study:

  • To investigate the cognitive performance outcomes of a single, lower dose (0.2 g/kg) of creatine monohydrate during sleep deprivation.
  • To compare the effects of creatine supplementation versus placebo on cognitive functions under sleep deprivation conditions.

Main Methods:

  • Twenty-nine healthy participants underwent cognitive testing after receiving either creatine monohydrate (0.2 g/kg) or a placebo.
  • Cognitive tests were administered at baseline and at 3, 5.5, and 7.5 hours during a 21-hour period of total sleep deprivation.
  • Performance was assessed on logical reasoning, numerical tasks, language processing speed, and the Psychomotor Vigilance Test (PVT).

Main Results:

  • Creatine supplementation at 0.2 g/kg significantly mitigated the deterioration of cognitive functions caused by sleep deprivation.
  • Specific improvements were observed in logical and numerical tasks, language processing speed, and the Psychomotor Vigilance Test (PVT).
  • Females exhibited greater benefits from creatine supplementation compared to males, particularly in logic, PVT, and language processing speed.

Conclusions:

  • A single dose of 0.2 g/kg creatine monohydrate effectively reduces cognitive performance decline during sleep deprivation.
  • While the effect is less pronounced than with a higher dose, creatine supplementation still offers cognitive benefits up to 12%.
  • The findings suggest creatine's potential as a countermeasure against sleep deprivation-induced cognitive impairment, with sex-specific differences in efficacy.