Related Experiment Video
Updated: May 5, 2026
06:04
Author Spotlight: Studying Clinical Characters and Epilepsy Outcomes After Frontal Disconnection in Patients with MOGHE
Published on: August 16, 2024
1.8K
Movement Disorders in MOGAD: A Systematic Review
Stefania Kalampokini1, Antonis Frontistis1, Antonis Pilavas2
11st Department of Neurology, AHEPA University Hospital, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece.
Medicina (Kaunas, Lithuania)
|May 4, 2026
Summary
Movement disorders like ataxia are common in Myelin Oligodendrocyte Glycoprotein-Associated Disease (MOGAD), often appearing at onset, especially in children. Early diagnosis and treatment with steroids can lead to significant recovery.
Area of Science:
- Neurology
- Neuroimmunology
- Movement Disorders
Background:
- Movement disorders are frequently overlooked in Myelin Oligodendrocyte Glycoprotein-Associated Disease (MOGAD).
- This study systematically reviews documented movement disorders in MOGAD patients.
Purpose of the Study:
- To summarize all movement disorders previously described in Myelin Oligodendrocyte Glycoprotein-Associated Disease (MOGAD).
Main Methods:
- A systematic literature search was performed across PubMed, Web of Science, and Scopus.
- Studies included patients diagnosed with MOGAD and exhibiting various movement disorders.
Main Results:
- Ninety-one patients from 58 studies were analyzed, with cerebellar ataxia being the most prevalent movement disorder (84.6%).
- Movement disorders often presented at MOGAD onset (70%), particularly in pediatric cases, with subcortical and cerebellar lesions common on imaging.
- Full recovery or significant improvement was observed in approximately 50% of patients following immunomodulatory treatment, primarily steroids.
Conclusions:
- The emergence of movement disorders, especially ataxia, warrants investigation for MOGAD, particularly in young patients.
- It may also signify a relapse in individuals with a pre-existing MOGAD diagnosis.
More Related Videos
Related Concept Videos
01:24Parkinson Disease ll: Pathophysiology
28
Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
28
01:15Parkinson's Disease: Overview
2.2K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
2.2K
01:20Gastrointestinal Motility Disorders
1.6K
Gastrointestinal or GI motility disorders are characterized by irregular gastrointestinal tract movements, disrupting food transit from the mouth to the anus. They are caused by damage or dysfunction in gut muscles or nerves. These disorders can cause symptoms such as severe constipation, diarrhea, abdominal pain, and swallowing difficulties. Disorders can affect any segment of the GI tract and range widely in severity, from common conditions like GERD to life-threatening conditions like...
1.6K
01:24Parkinson Disease l: Introduction
28
Parkinson’s disease is a chronic, progressive neurodegenerative disorder that primarily affects movement. It is characterized by motor symptoms such as resting tremors, muscle rigidity, bradykinesia (slowness of movement), and postural instability. Patients may notice hand tremors at rest, stiffness during movement, or a shuffling gait. In addition to motor features, non-motor symptoms include sleep disturbances, mood and behavioral changes, constipation, and cognitive impairment, all of...
28
01:24Parkinson's Disease: Treatment
1.4K
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
1.4K
01:11Alterations in Muscle Tone lll
29
Rigidity and myotonia are distinct abnormalities of muscle tone that affect resistance and relaxation during movement. Although both involve altered muscle contraction, they arise from different neurological and muscular mechanisms.CharacteristicsRigidity is characterized by uniform resistance to passive movement across the entire range, independent of speed, affecting flexors and extensors equally. It may appear as lead-pipe rigidity (smooth, constant resistance) or cogwheel rigidity...
29