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Evaluating Formulation-Dependent Chemical Variation and Comparability of Maziren-Wan Preparations via Multi-Component
1KM Science Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of Korea.
Pharmaceuticals (Basel, Switzerland)
|May 4, 2026
Summary
Maziren-Wan (MZRW) preparations show chemical differences based on formulation, impacting quality assessment. Analyzing multiple marker compounds is key to ensuring consistency in this traditional herbal medicine.
Area of Science:
- Pharmaceutical Sciences
- Herbal Medicine Analysis
- Analytical Chemistry
Background:
- Maziren-Wan (MZRW) is a traditional herbal prescription for chronic constipation.
- Available in granules and decoctions, its multi-component nature necessitates quality assessment.
- Evaluating chemical consistency across different MZRW preparations is crucial.
Purpose of the Study:
- To compare formulation-dependent chemical profiles of MZRW preparations.
- To utilize a multi-component analytical approach for quality assessment.
- To investigate variations in marker compound levels among different MZRW products.
Main Methods:
- Analysis of an excipient-free reference extract and two commercial MZRW granules.
- Utilized validated liquid chromatography-tandem mass spectrometry (LC-MS/MS).
- Simultaneously quantified 30 marker compounds and compared their levels statistically.
Main Results:
- Significant formulation-dependent variations in marker compound abundance were observed.
- Amygdalin and magnoloside A levels were higher in the reference extract compared to commercial granules.
- Sennoside A levels remained relatively consistent across all analyzed preparations.
Conclusions:
- MZRW preparations with identical herbal composition can display formulation-dependent chemical profile differences.
- Multi-component analysis aids in assessing chemical consistency of MZRW.
- This approach supports quality assessment for MZRW formulated under various conditions.
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