Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

¹H NMR: Long-Range Coupling01:27

¹H NMR: Long-Range Coupling

2.4K
The coupling interactions of nuclei across four or more bonds are usually weak, with J values less than 1 Hz. While these are usually not observed in spectra, the presence of multiple bonds along the coupling pathway can result in observable long-range coupling.
In alkenes, spin information is communicated via σ–π overlap, as seen in allylic (four-bond) and homoallylic (five-bond) couplings. These coupling interactions are stronger when the σ bond is parallel to the alkene...
2.4K
Hybridization of Atomic Orbitals II03:35

Hybridization of Atomic Orbitals II

36.5K
sp3d and sp3d 2 Hybridization
36.5K
π Molecular Orbitals of 1,3-Butadiene01:24

π Molecular Orbitals of 1,3-Butadiene

8.6K
Conjugated dienes have lower heats of hydrogenation than cumulated and isolated dienes, making them more stable. The enhanced stabilization of conjugated systems can be understood from their π molecular orbitals.
The simplest conjugated diene is 1,3-butadiene: a four-carbon system where each carbon is sp2-hybridized and has an unhybridized p orbital that contains an unpaired electron. According to molecular orbital theory, atomic orbitals combine to form molecular orbitals such that the...
8.6K
π Electron Effects on Chemical Shift: Overview01:27

π Electron Effects on Chemical Shift: Overview

1.5K
An applied magnetic field causes loosely bound π-electrons in organic molecules to circulate, producing a local or induced diamagnetic field over a large spatial volume. As the molecules tumble in solution, the field generated by π-electrons in spherical substituents results in a zero net field. However, the net field generated by π-electrons in non-spherical substituents is not zero. The effect of this induced field depends on the orientation of the molecule with respect to B0,...
1.5K
Nucleic Acid Structure01:25

Nucleic Acid Structure

8.1K
The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA...
8.1K
Structures of Carboxylic Acid Derivatives01:28

Structures of Carboxylic Acid Derivatives

3.1K
Structure of Carboxylic Acid Derivatives
Carboxylic acid derivatives contain an acyl group attached to a heteroatom such as chlorine, oxygen, or nitrogen. The carbonyl carbon and oxygen are both sp2-hybridized with an unhybridized p orbital.
The three sp2 orbitals of the carbonyl carbon form three σ bonds, one each with the carbonyl oxygen, the α carbon, and the heteroatom, whereas the other two sp2 orbitals of the carbonyl oxygen are occupied by the lone pairs. Further, the...
3.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dioxocobaltate(II) Anions in Alkaline Earth-Lanthanum Germanate Apatites: Magnetic Anisotropy and Correlated Dual Slow Relaxation of Magnetization.

Inorganic chemistry·2026
Same author

High-pressure powder x-ray diffraction cell for soft materials.

The Review of scientific instruments·2026
Same author

Making room for reactivity in topochemical transformations under pressure.

Chemical science·2026
Same author

Investigation of the La-Al-H and La-Si-H Systems at High Pressures.

Inorganic chemistry·2026
Same author

Inorganic Single-Ion Magnet DyO<sup>+</sup> in the Apatite-Type Structure of (Ca,Sr)<sub>10</sub>(VO<sub>4</sub>)<sub>6</sub>(OH)<sub>2</sub>.

Inorganic chemistry·2025
Same author

Unlocking the Potential of Cobalt-Free Lithium-Ion Cathodes via Lithium-Rich Disorder Domains.

ACS nano·2025
Same journal

Correction: Chen et al. Chemical Composition of <i>Litsea pungens</i> Essential Oil and Its Potential Antioxidant and Antimicrobial Activities. <i>Molecules</i> 2023, <i>28</i>, 6835.

Molecules (Basel, Switzerland)·2026
Same journal

Correction: Ruan et al. Comparison of Extraction, Isolation, Purification, Structural Characterization and Immunomodulatory Activity of Polysaccharides from Two Species of <i>Cistanche</i>. <i>Molecules</i> 2025, <i>30</i>, 4754.

Molecules (Basel, Switzerland)·2026
Same journal

Correction: Li et al. Gastrodin Ameliorates Cognitive Dysfunction in Vascular Dementia Rats by Suppressing Ferroptosis via the Regulation of the Nrf2/Keap1-GPx4 Signaling Pathway. <i>Molecules</i> 2022, <i>27</i>, 6311.

Molecules (Basel, Switzerland)·2026
Same journal

Correction: Zueva et al. Steady-State Kinetics of Enzyme-Catalyzed Hydrolysis of Echothiophate, a P-S Bonded Organophosphorus as Monitored by Spectrofluorimetry. <i>Molecules</i> 2020, <i>25</i>, 1371.

Molecules (Basel, Switzerland)·2026
Same journal

1,4-Diazatriphenylene and Its Hetero-Fused Analogs: Synthesis and Applications.

Molecules (Basel, Switzerland)·2026
Same journal

Comparative Phytochemical Studies on the Aerial Parts of <i>Teucrium davaeanum</i> Coss. and <i>Teucrium zanonii</i> Pamp.

Molecules (Basel, Switzerland)·2026
See all related articles

Related Experiment Video

Updated: May 5, 2026

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
09:04

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

Published on: September 21, 2017

10.5K

N-Methylated Nucleobases Crystal Structures and π-π Stacking Interactions.

Riccardo Cameli Manzo1,2, Volodymyr Baran1, Artem Shevchenko2

  • 1Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607 Hamburg, Germany.

Molecules (Basel, Switzerland)
|May 4, 2026
PubMed
Summary
This summary is machine-generated.

This study explores the solid-state structures of methylated purine bases, revealing insights into their intermolecular geometries. Findings show N-methylated purines follow predicted trends in pi-pi stacking and hydrogen bonding.

Keywords:
SC-XRDXRPDmethyladeninesmethylguaninesnucleobasessolid-statesynchrotron-XRPDπ-π stacking

More Related Videos

Analyzing and Building Nucleic Acid Structures with 3DNA
16:24

Analyzing and Building Nucleic Acid Structures with 3DNA

Published on: April 26, 2013

20.3K
Author Spotlight: Characterizing DNA G-Quadruplex by Bis-3-Chloropiperidine Based Chemical Mapping
05:32

Author Spotlight: Characterizing DNA G-Quadruplex by Bis-3-Chloropiperidine Based Chemical Mapping

Published on: May 12, 2023

2.0K

Related Experiment Videos

Last Updated: May 5, 2026

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
09:04

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

Published on: September 21, 2017

10.5K
Analyzing and Building Nucleic Acid Structures with 3DNA
16:24

Analyzing and Building Nucleic Acid Structures with 3DNA

Published on: April 26, 2013

20.3K
Author Spotlight: Characterizing DNA G-Quadruplex by Bis-3-Chloropiperidine Based Chemical Mapping
05:32

Author Spotlight: Characterizing DNA G-Quadruplex by Bis-3-Chloropiperidine Based Chemical Mapping

Published on: May 12, 2023

2.0K

Area of Science:

  • Solid-state chemistry
  • Crystallography
  • Molecular structure

Background:

  • Intermolecular geometries of methylated nucleobases in the solid state are not well-documented.
  • Methylated purines are significant in biological systems and drug development.

Purpose of the Study:

  • To systematically investigate the solid-state structures of 1-, 3-, and 7-methylated adenines and guanines.
  • To analyze hydrogen bonding and pi-pi stacking interactions in these methylated nucleobases.

Main Methods:

  • Single-crystal X-ray diffraction
  • Synchrotron/laboratory X-ray powder diffraction (XRPD)
  • In situ high-temperature XRPD
  • Differential thermal analysis/thermogravimetry (DTA/TG)

Main Results:

  • Crystal structures of methylated adenines and guanines, including hydrates, were determined.
  • High-temperature XRPD and DTA/TG revealed water removal effects and a new polymorph for 3-methyladenine.
  • Hydrogen bonding forms ribbon planar or linear double-bonded motifs.
  • Pi-pi stacking interactions align with theoretical predictions for N-methylated purine bases.

Conclusions:

  • This research provides the first systematic experimental data on the solid state of these methylated purine compounds.
  • The findings enhance understanding of nucleobase interactions in crystalline environments.
  • The study validates theoretical models for pi-pi stacking in N-methylated purines.