Advances in Ultrasonic Rehabilitation

The fundamental differences between high- and low-frequency ultrasound for medical purposes were demonstrated. A model describing the effect of ultrasound on erythrocyte aggregation was developed, and the rapid movement of erythrocytes toward the nodes of a standing acoustic wave was demonstrated, with its velocity compared to the rate of erythrocyte dissociation under the influence of shear forces. The t-test was used to assess the statistical significance of differences between two blood samples and confirmed the effect of low-frequency ultrasound intensity on erythrocyte aggregation. The study employed a patented low-frequency ultrasound transducer generating a traveling acoustic wave that produces shear forces capable of disrupting erythrocyte aggregates into individual erythrocytes. Since the developed technique is intended for human therapy, it is assumed that the proposed low-frequency ultrasound parameters are safe for flowing blood. Due to deeper and more precise penetration of the acoustic signal into tissues, this ultrasound transducer may be promising for improving microcirculation and alleviating patient condition without medication, as well as for reducing blood pressure and heart rate. The developed technique also enables more effective disruption of heart valve plaques and shows therapeutic potential for tumor treatment and in vivo drug encapsulation. Since erythrocytes in diabetic patients are stiffer than those in healthy individuals, their passage through capillaries is more difficult. Therefore, the developed and patented ultrasound-based sole stimulation technique may produce a positive physiological effect by stimulating blood flow in the capillaries of patients with foot ulcers.