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An Au25 Nanocluster-Based Electrochemical Biosensor for Profenofos Detection With High Activity and Sensitivity
Yuying Zhang1, Jianfang Qin1, Mengxi Zhang1
1Department of Applied Chemistry, Yuncheng University, Yuncheng, Shanxi, China.
Chemistry (Weinheim an Der Bergstrasse, Germany)
|May 4, 2026
Summary
This study presents a novel electrochemical sensor using gold nanoclusters (Au25) for detecting the pesticide profenofos. The developed biosensor shows high sensitivity and stability for environmental monitoring.
Area of Science:
- Cluster Chemistry
- Electrochemical Sensing
- Biosensor Development
Background:
- Metal nanoclusters offer potential for electrochemical sensing, but applications are emerging.
- Developing sensitive and stable sensors for environmental pollutants like pesticides is crucial.
Purpose of the Study:
- To fabricate and optimize a novel electrochemical sensor for profenofos detection.
- To explore the application of atomic-precision gold nanoclusters in environmental monitoring.
Main Methods:
- Fabrication of a three-layer KBE-CS/Au25@MLG/GC electrode.
- Utilizing kidney bean enzyme (KBE), chitosan (CS), multilayer graphene (MLG), and gold nanoclusters (Au25).
- Electrochemical detection of profenofos inhibition rates.
Main Results:
- The sensor exhibited a wide linear range (1–2000 µg/L) for profenofos detection.
- Achieved a low detection limit of 0.137 µg/L.
- Demonstrated excellent reproducibility, anti-interference, and stability in real samples.
Conclusions:
- The Au25-based sensor provides a high-performance platform for electrochemical pesticide detection.
- This work facilitates the practical application of metal nanoclusters in environmental sensing.
- Paves the way for cluster-based detection platforms.
