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Molecular Mechanisms of Programmed Cell Death Pathways in Chronic Obstructive Pulmonary Disease
Yuchen Zhuang1, Lan Yao1, Wenchuan Qi1,2
1College of Acupuncture-Moxibustion and Tuina, Chengdu University of TCM, Chengdu, Sichuan Province, China.
Journal of Cellular Physiology
|May 4, 2026
Summary
Chronic obstructive pulmonary disease (COPD) involves complex cell interactions and programmed cell death (PCD) pathways. Understanding these mechanisms offers new therapeutic strategies for COPD patients.
Area of Science:
- Pulmonary Medicine
- Cell Biology
- Pathology
Background:
- Chronic obstructive pulmonary disease (COPD) is a progressive respiratory disease affecting over 400 million globally.
- Pathogenesis involves alveolar and airway epithelial cells, and inflammatory cells, leading to lung damage and inflammation.
Purpose of the Study:
- To review programmed cell death (PCD) modes in COPD pathogenesis.
- To explore molecular mechanisms and crosstalk of seven PCD processes: apoptosis, necroptosis, ferroptosis, autophagy, pyroptosis, cuproptosis, and disulfidptosis.
- To discuss clinical treatment strategies for COPD based on PCD regulation.
Main Methods:
- Literature review focusing on programmed cell death (PCD) mechanisms in COPD.
- Analysis of cell-type-specific pathways involved in COPD.
- Examination of clinical treatment strategies linked to PCD modulation.
Main Results:
- Multiple PCD pathways, including apoptosis, necroptosis, ferroptosis, autophagy, pyroptosis, cuproptosis, and disulfidptosis, are implicated in COPD initiation and progression.
- Interactions between these PCD modes contribute to lung damage and inflammation in COPD.
- PCD regulation presents potential therapeutic targets for both acute and stable COPD phases.
Conclusions:
- Understanding cell-type-specific PCD mechanisms enhances comprehension of COPD phenotypes.
- This knowledge provides a theoretical basis for novel therapeutic strategies targeting COPD's molecular pathology.
- Targeting PCD offers a promising avenue for developing new treatments for chronic obstructive pulmonary disease.
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