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Updated: May 5, 2026
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Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
Published on: June 15, 2019
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Cuproptosis in Sepsis: Cell Type-Specific Mechanisms and Clinical Prospects
Shangping Fang1, Wanning Li1, Zhaorong Chang1
1School of Anesthesiology, Wannan Medical University, Wuhu, Anhui, People's Republic of China.
Drug Design, Development and Therapy
|May 4, 2026
Summary
Cuprotosis, a copper-dependent cell death pathway, significantly contributes to sepsis-induced immune dysfunction and organ failure. Targeting cuprotosis presents a potential therapeutic strategy for sepsis, pending clinical validation.
Area of Science:
- Biochemistry
- Immunology
- Cell Biology
Background:
- Sepsis is a life-threatening condition with high mortality due to a dysregulated host response to infection.
- Cuprotosis is a novel, copper-dependent mitochondrial cell death pathway distinct from apoptosis and pyroptosis.
Purpose of the Study:
- To outline cuprotosis mechanisms.
- To elucidate its role in sepsis pathophysiology.
- To evaluate targeting cuprotosis for sepsis therapy.
Main Methods:
- Systematic review of cuprotosis mechanisms.
- Analysis of cuprotosis's role in sepsis-induced immune dysfunction and organ failure.
- Evaluation of therapeutic potential and challenges.
Main Results:
- Cuprotosis mediates the death of immune and parenchymal cells in sepsis.
- This cell death pathway contributes to immune dysfunction and organ failure.
- Cuprotosis is mechanistically distinct from other cell death pathways.
Conclusions:
- Cuprotosis plays a significant role in sepsis pathogenesis.
- Modulating cuprotosis offers a potential therapeutic avenue for sepsis.
- Further clinical validation is necessary to establish cuprotosis-targeted therapies.
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