Angiomatoid fibrous histiocytoma: first report of adjacent venous invasion

Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue neoplasm predominantly occurring in the extremities of children and young adults. This report presents an 8-year-old girl with AFH involving the superficial femoral vein. The patient was successfully managed with complete tumor resection and vascular reconstruction. No local recurrence or distant metastasis was detected during the 12-month follow-up. To our knowledge, this is the first reported case of AFH with direct vascular invasion. Our findings suggest that complete surgical resection remains the primary treatment, and vascular involvement may not necessarily indicate a malignant phenotype in AFH.