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Research progress on novel bionic cryoprotectants in gamete and embryo cryopreservation
Lidan Yang1,2, Zesen Yang1, Ximo Guo2
1College of Life Sciences, Hebei Agricultural University, Baoding, China.
Frontiers in Veterinary Science
|May 4, 2026
Summary
Novel bioinspired cryoprotectants offer a safer, more effective alternative for preserving animal genetic resources. These substances mimic natural antifreeze, reducing toxicity and enhancing cryopreservation of gametes and embryos.
Area of Science:
- Biomedical Science
- Cryobiology
- Animal Genetics
Background:
- Cryopreservation is vital for preserving animal genetic resources.
- Traditional cryoprotectants face limitations due to cytotoxicity.
- Developing non-toxic, effective cryoprotectants is a research priority.
Purpose of the Study:
- To review cryopreservation technology and cryoprotectant mechanisms.
- To focus on novel bioinspired cryoprotectants.
- To analyze their application in animal gamete preservation.
Main Methods:
- Systematic review of cryopreservation history and principles.
- Classification and mechanism analysis of cryoprotectants.
- Focus on five types of bioinspired cryoprotectants.
Main Results:
- Bioinspired cryoprotectants mimic natural antifreeze structures.
- These novel protectants exhibit low toxicity and high efficiency.
- Analyzed ice-suppression performance and mechanisms of action.
Conclusions:
- Bioinspired cryoprotectants show significant potential for animal gamete (sperm, oocytes, embryos) cryopreservation.
- They offer enhanced efficiency and reduced toxicity compared to traditional options.
- Expanding their use can advance animal genetic resource preservation.
