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An infection and pathogenesis mouse model of SARS-CoV-2-related pangolin coronavirus GX_P2V(short_3UTR)
Lai Wei1, Shuiqing Liu1, Shanshan Lu1
1College of Life Science and Technology Beijing University of Chemical Technology Beijing China.
Abstract:
SARS-CoV-2-related pangolin coronavirus GX_P2V(short_3UTR) is highly attenuated, but can cause mortality in a specifically designed human ACE2-transgenic mouse model, making it a surrogate model for evaluating the efficacy of vaccines and drugs against SARS-CoV-2.
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