Risk Factors for Anti-Glaucoma Surgery in Posner-Schlossman Syndrome Patients: an 8-Year Retrospective Study

Area of Science:

• Ophthalmology
• Glaucoma Research
• Surgical Risk Factors

Background:

• Posner-Schlossman Syndrome (PSS) is a recurrent uveitis condition.
• Identifying risk factors for anti-glaucoma surgery is crucial for managing PSS patients.
• Previous studies have not comprehensively evaluated surgical risk in this population.

Purpose of the Study:

• To investigate the risk factors associated with the need for anti-glaucoma surgery in Chinese patients diagnosed with Posner-Schlossman Syndrome.
• To identify specific clinical and demographic predictors that influence surgical outcomes in PSS.

Main Methods:

• A retrospective study was conducted involving 106 Chinese Posner-Schlossman Syndrome patients.
• Patients were categorized into low-frequency (<2 attacks/year) and high-frequency (≥2 attacks/year) groups.
• Data on general information, ocular manifestations, and medical treatments were collected and analyzed, with a focus on risk factors for anti-glaucoma surgery.

Main Results:

• The high-frequency attack group exhibited longer disease duration, more iris atrophy, and increased use of systemic ganciclovir.
• Patients with higher attack frequency had a greater tendency for secondary glaucoma and a higher probability of requiring anti-glaucoma surgery.
• Binary logistic regression identified older age of onset (OR=1.080), higher attack frequency (OR=6.186), and RNFL defect (OR=4.804) as significant risk factors for anti-glaucoma surgery.

Conclusions:

• Elderly age of onset, increased frequency of attacks, and the presence of RNFL defects are significant risk factors for undergoing anti-glaucoma surgery in Posner-Schlossman Syndrome patients.
• These findings aid in predicting surgical necessity and optimizing treatment strategies for PSS.
• Further research could explore preventative measures against these identified risk factors.