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Updated: May 6, 2026
An Immature Murine Model of Reversible Unilateral Ureteral Obstruction
Published on: April 4, 2025
Wire-Calibrated Induction of Segmental Ureteral Strictures in Rats via Midline Laparotomy
Alexander Studier-Fischer1, Paula Grützner2, Berkin Özdemir3
1Department of Urology and Urosurgery, University Medical Center Mannheim, Medical Faculty of the University of Heidelberg; Department of General, Visceral, and Transplantation Surgery, Heidelberg University Hospital; Division of Intelligent Systems and Robotics in Urology (ISRU), German Cancer Research Center (DKFZ) Heidelberg; DKFZ Hector Cancer Institute at the University Medical Center Mannheim; alexander@studier-fischer.com.
Researchers developed a reproducible rat model to study ureteral strictures, a common challenge in reconstructive urology. This model aids research into treatments for obstructive uropathy and kidney function loss.
Area of Science:
- Urology
- Surgical Innovation
- Preclinical Research
Background:
- Ureteral strictures are a significant clinical problem in reconstructive urology.
- Causes include iatrogenic injury, inflammation, trauma, congenital issues, and radiation.
- Strictures lead to obstructive uropathy and renal function decline, necessitating better research models.
Purpose of the Study:
- To establish a reproducible preclinical model for inducing ureteral strictures in rats.
- To create a platform for studying the effects and treatments of ureteral stricture disease.
Main Methods:
- Utilized wire-calibrated partial ligation via midline laparotomy in rats.
- Developed a non-transecting constriction method to mimic fibrotic narrowing.
- Ensured macroscopic tissue viability and ureteral continuity.
Main Results:
- Successfully created a reproducible rat model for segmental ureteral strictures.
- Achieved controlled induction of varying stricture degrees with low variability.
- The model minimizes ischemic damage while maintaining ureteral integrity.
Conclusions:
- The established rat model offers a reliable platform for translational research.
- Facilitates investigation into biomolecular mechanisms, biomaterials, and surgical techniques for ureteral strictures.
- Supports advancements in treating obstructive uropathy and preserving renal function.
