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Updated: May 6, 2026
05:28
Author Spotlight: Enhancing Upper Limb Rehabilitation in Stroke Patients Through Advanced Robotic and Neuromodulation Technologies
Published on: October 11, 2024
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Maraviroc for Stroke Recovery (MASTER): protocol for a phase 2 double-blind placebo-controlled randomised clinical
Nicolas Broc1,2, Gabriel Byczynski1,2, Elisabeth Dirren1
1Geneva University Hospital, Geneva, Switzerland.
BMJ Open
|May 4, 2026
Summary
This study investigates Maraviroc, a C-C chemokine Receptor 5 (CCR5) antagonist, to improve upper limb motor recovery in stroke patients. The trial aims to determine if CCR5 inhibition enhances neuroplasticity and functional outcomes post-stroke.
Area of Science:
- Neuroscience
- Pharmacology
- Clinical Trials
Background:
- Stroke is a leading cause of acquired disability with limited pharmacological options for post-acute recovery.
- Preclinical data suggest C-C chemokine Receptor 5 (CCR5) inhibition may enhance neuroplasticity and recovery.
- The efficacy of CCR5 antagonists in human ischemic stroke recovery remains unestablished.
Purpose of the Study:
- To evaluate the efficacy and safety of Maraviroc, a CCR5 antagonist, for improving upper limb motor function after ischemic stroke.
- To assess the impact of Maraviroc on motor learning and peri-infarct neuroplasticity.
Main Methods:
- A phase II, randomized, double-blind, placebo-controlled trial involving 80 ischemic stroke patients with moderate upper extremity impairment.
- Participants receive standard rehabilitation plus either oral Maraviroc (300 mg twice daily) or placebo for 90 days.
- Primary outcome: Fugl-Meyer Assessment for Upper Extremity at 90 days. Secondary outcomes: MRI-assessed motor learning and neuroplasticity.
Main Results:
- This section is to be filled once the trial concludes and results are available.
Conclusions:
- This section is to be filled once the trial concludes and results are available.
Keywords:
Clinical TrialMagnetic resonance imagingREHABILITATION MEDICINERandomized Controlled TrialStrokeMore Related Videos
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