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Updated: May 6, 2026
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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
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Cyclodextrins: Synthesis, Pharmaceutical Applications, Drug Delivery Systems and Safety Perspectives.
Aman Kumar1, Ravi Raj Pal1, Preeti Patel2
1Department of Pharmaceutics, ISF College of Pharmacy, GT Road, Moga, 142001, Punjab, India.
AAPS Pharmscitech
|May 4, 2026
Summary
Cyclodextrins (CDs) enhance drug solubility and stability by forming complexes, addressing a key challenge in pharmaceutical development. These versatile excipients improve drug delivery and formulation performance.
Area of Science:
- Supramolecular Chemistry
- Pharmaceutical Sciences
- Biochemistry
Background:
- Poor aqueous solubility of drug molecules hinders formulation, bioavailability, and efficacy.
- Cyclodextrins (CDs) are cyclic oligosaccharides with versatile pharmaceutical applications.
- CDs form inclusion and non-inclusion complexes to improve drug properties.
Purpose of the Study:
- To provide a comprehensive review of cyclodextrins (CDs) as pharmaceutical excipients.
- To discuss the synthesis, structural characteristics, and advanced analytical techniques for CDs.
- To evaluate the pharmaceutical, cosmetic, and dermopharmaceutical applications of CDs.
Main Methods:
- Review of literature on cyclodextrin synthesis, characterization, and applications.
- Emphasis on cyclodextrin glucanotransferase (CGTase) catalyzed reactions.
- Discussion of advanced structural elucidation techniques (X-ray crystallography, NMR, simulations, MS).
Main Results:
- CDs significantly enhance drug solubility, stability, and dissolution rates.
- CGTase enzyme plays a critical role in cyclodextrin synthesis via transglycosylation reactions.
- Advanced techniques provide detailed structural insights into CD-drug interactions.
Conclusions:
- Cyclodextrins are crucial excipients bridging supramolecular chemistry and drug delivery.
- CDs offer solutions for solubility challenges and improve therapeutic efficacy.
- Applications extend to cosmetics and dermopharmaceuticals, enabling controlled delivery.
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