Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.1K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.1K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

1.5K
1.5K
Cancer Therapies02:49

Cancer Therapies

8.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
8.6K
Cancer Therapies02:49

Cancer Therapies

2.4K
2.4K
Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

11.9K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
11.9K
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

1.1K
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Recent Advances in Pectin-Based Materials for Therapeutic Applications: A Review.

Current pharmaceutical design·2026
Same author

Dentinal Grafts, a Promising Material for Alveolar Defects: A Systematic Review and Meta-Analysis.

Dentistry journal·2026
Same author

Design and Evaluation of a Thiourea-Based Sensor for Hg<sup>2+</sup> Detection and Antimicrobial Activity.

Journal of fluorescence·2026
Same author

Dual-function thiourea-linked benzothiazole derivative: sensitive fluorescent detection of Hg<sup>2+</sup> and broad-spectrum antibacterial and antifungal activity.

Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes·2025
Same author

Medicinal and Chemosensing Applications of Chitin-Based Materials: A Comprehensive Review.

Journal of fluorescence·2025
Same author

Bacterial profiling and antibiotic resistance patterns in urinary tract infections: a microbiological analysis from Dera Isamil Khan, Pakistan.

BMC infectious diseases·2025

Related Experiment Video

Updated: May 6, 2026

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
11:14

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay

Published on: November 10, 2013

57.6K

Metal-based Chemotherapeutics Targeting Oral Cancer: A Review.

Fahad Saeed Algahtani1, Mohammed Abdullah Alzubaidi2, Abdullah M Al Shumrani2

  • 1Department of Restorative Dental Science, Faculty of Dentistry, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.

Mini Reviews in Medicinal Chemistry
|May 5, 2026
PubMed
Summary

Metal-based drugs show promise for treating oral cancer by inducing cell death and targeting cancer pathways. This review explores coordination complexes, MOFs, and nanoparticles for oral cancer therapy.

Keywords:
AnticancerMOFsapoptosisbiocompatibleoral canceroxidative stress

More Related Videos

Translationally-Relevant Tumor Resection Model for Murine Preclinical Models of Oral Squamous Cell Carcinoma
07:44

Translationally-Relevant Tumor Resection Model for Murine Preclinical Models of Oral Squamous Cell Carcinoma

Published on: April 3, 2026

134
Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
07:29

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

11.4K

Related Experiment Videos

Last Updated: May 6, 2026

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
11:14

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay

Published on: November 10, 2013

57.6K
Translationally-Relevant Tumor Resection Model for Murine Preclinical Models of Oral Squamous Cell Carcinoma
07:44

Translationally-Relevant Tumor Resection Model for Murine Preclinical Models of Oral Squamous Cell Carcinoma

Published on: April 3, 2026

134
Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
07:29

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

11.4K

Area of Science:

  • Oncology
  • Materials Science
  • Nanotechnology

Background:

  • Oral cancer, primarily oral squamous cell carcinoma (OSCC), presents a significant global health challenge due to late diagnosis and limited treatments.
  • Metal-based chemotherapeutics offer unique physicochemical properties for cancer treatment, inducing apoptosis through various mechanisms.
  • Metal complexes can disrupt cancer pathways and suppress cancer-related gene expression.

Purpose of the Study:

  • To review the applications and recent developments of metal-based drugs in oral cancer treatment.
  • To highlight the mode of action, clinical applications, and biocompatibility of these agents.
  • To provide guidance for developing novel metal-based chemotherapeutics for oral cancer.

Main Methods:

  • Review of existing literature on metal-based drugs for oral cancer.
  • Focus on coordination complexes, metal-organic frameworks (MOFs), and metal/metal oxide nanoparticles.
  • Analysis of mechanisms of action, clinical relevance, and biocompatibility.

Main Results:

  • Metal-based drugs, including coordination complexes and MOFs, demonstrate potential in inducing apoptosis and targeting OSCC.
  • MOFs serve as biocompatible carriers for targeted drug delivery, releasing agents at acidic tumor pH.
  • Metal/metal oxide nanoparticles offer diverse therapeutic and diagnostic applications in oral cancer.

Conclusions:

  • Metal-based agents represent a promising strategy for oral cancer therapy, offering novel mechanisms of action.
  • Hybrid approaches like MOFs provide tunable and biocompatible platforms for drug delivery and treatment.
  • Further research and development in metal-based chemotherapeutics are crucial for advancing oral cancer care.