Splicing: A New Dimension in Decoding the Complex Traits for Cervical Cancer

Cervical cancer continues to pose a significant global health chal-lenge, with relatively high incidence and mortality rates among gynecological malignancies, particularly in developing countries. Complex etiological factors, including genetic predispo-sition, environmental influences, and biological mechanisms, regulate the progression of cer-vical cancer. Recent advances in understanding RNA splicing have contributed to a more de-tailed elucidation of these complexities, presenting a promising avenue for cervical cancer research. Here, we elucidate how alternative splicing events promote the synthesis of diverse protein isoforms that modulate tumorigenesis, progression, and metastasis.

A PubMed and Google Scholar-based literature search was performed to identify genes involved in splicing mechanisms as biomarkers for cervical cancer. The search covered studies published between 2000 and 2024. The following keywords were used: "splicing," "splicing factors/genes," "gene regulation," "spliceosomes," "splicing as cancer hallmark," and "splicing mechanisms," in combination with "cervical cancer." We included only English-language publications related specifically to splicing in cervical cancer.

We consolidated major splicing factors identified across genomic studies, clinical research, and mechanistic evaluations related to cervical cancer, which may serve as signifi-cant prognostic and diagnostic biomarkers.

These consolidated findings highlight the potential impact of splicing on clinical decision-making, various therapeutic modalities, and personalized medicine. Furthermore, therapeutic strategies targeting splicing mechanisms could lead to novel interventions that im-prove clinical outcomes in cervical cancer patients.