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Related Concept Videos

Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

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Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
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Mitral Regurgitation III: Medical Management01:25

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Mitral regurgitation (MR) is characterized by retrograde blood circulation from the left ventricle into the left atrium due to inadequate mitral valve closure. The severity of the condition, symptoms, and underlying cause determine treatment strategies.Monitoring and Pharmacological TreatmentPatients with mild to moderate MR typically do not need immediate intervention but regular monitoring to assess progression and guide treatment. Patients with mild MR should have an echocardiogram every 3-5...
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Mitral Valve Prolapse II: Assessment and Management01:22

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IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular...
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Mitral Valve Prolapse I: Introduction01:27

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IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
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Mitral Valve Prolapse III: Nursing Management01:19

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The nursing management of Mitral Valve Prolapse, or MVP, centers around patient education, symptom monitoring, and lifestyle modifications.Patient Education on MVP Diagnosis and Heredity: Nurses should provide comprehensive education about MVP, a condition where the mitral valve does not close appropriately during heartbeats. This education often includes the condition's pathophysiology, symptoms, and potential complications, like arrhythmias or mitral regurgitation. Though not fully...
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Mitral Regurgitation II: Clinical Features and Diagnostic Tests01:23

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Mitral regurgitation (MR) is a valvular heart disorder in which the mitral valve fails to close tightly, allowing blood to leak backward into the heart. Understanding the clinical manifestations, assessment, diagnostic findings, and medical management of MR is crucial to effectively managing affected patients.Clinical Manifestations of Mitral RegurgitationMitral regurgitation can be acute or chronic, each presenting differently and requiring different approaches:1. Acute Mitral...
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Small Mitral Valve Orifice Area in Mitral Valve Transcatheter Edge-to-Edge Repair: The REPAIR Study.

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  3. Transcatheter Mitral Valve Replacement.
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A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair
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Transcatheter mitral valve replacement.

Tobias Friedrich Ruf1, Theresa Ann-Marie Gößler2, Philipp Lurz2

  • 1Zentrum für Kardiologie, Universitätsmedizin Mainz der Johannes Gutenberg Universität Mainz, Langenbeckstraße 1, 55131, Mainz, Germany. tobias.ruf@unimedizin-mainz.de.

Herz
|May 5, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

Transcatheter mitral valve replacement is emerging as a crucial therapy for specific mitral valve diseases like regurgitation and stenosis. This review explores current and investigational devices, their applications, and limitations.

Keywords:
Dedicated transcatheter devicesInterventional imagingMitral regurgitationMitral valve insufficiencyMitral valve stenosis

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Area of Science:

  • Cardiovascular Medicine
  • Interventional Cardiology

Background:

  • Transcatheter mitral valve interventions are increasingly used, primarily for mitral regurgitation (MR).
  • Transcatheter edge-to-edge repair is standard, but mitral valve replacement is necessary for certain MR types, stenosis, and calcification.
  • Limited approved devices exist despite numerous developments.

Purpose of the Study:

  • To review current transcatheter mitral valve replacement (TMVR) therapies.
  • To discuss investigational TMVR devices and their clinical trial status.
  • To highlight indications, potential, and limitations of TMVR devices.

Main Methods:

  • Literature review of transcatheter mitral valve replacement therapies.
  • Analysis of approved and investigational TMVR devices.
  • Examination of clinical trial data and regulatory approvals (CE Mark, FDA).

    • Main Results:

    • Transcatheter edge-to-edge repair is established for MR, but TMVR is crucial for specific anatomies.
    • TMVR is the only option for non-rheumatic mitral stenosis and mitral annular calcification.
    • Few TMVR devices have CE Mark and FDA approval, with many still in clinical trials.

    Conclusions:

    • TMVR offers a vital alternative for patients unsuitable for repair.
    • Further development and regulatory approval of TMVR devices are needed.
    • Understanding device-specific indications, potential, and limitations is key for optimal patient selection.