Cu/Ce multivalent metal-organic frameworks: polydopamine-electronic modulation for multi-enzyme activity and...

Area of Science:

• Materials Science
• Analytical Chemistry
• Nanotechnology

Background:

• Multi-target detection requires enhanced accuracy and flexibility.
• Developing integrated analytical platforms is crucial for advanced sensing.

Purpose of the Study:

• To construct a fluorescence-colorimetric dual-mode sensing platform.
• To utilize Cu/Ce multivalent metal-organic frameworks (Cu/Ce-MOFs) coated with polydopamine (PDA).
• To enable simultaneous detection of diverse analytes.

Main Methods:

• In-situ coating of polydopamine (PDA) on Cu/Ce-MOFs.
• Characterization of the synthesized Cu/Ce-MOFs@PDA material.
• Evaluation of the platform's dual-mode sensing capabilities for pesticides, phenolic pollutants, and biomolecules.

Main Results:

• The Cu/Ce-MOFs@PDA exhibited excellent fluorescent properties and multienzyme-like nanozyme activity.
• Synergistic redox cycling (Ce⁴⁺/Ce³⁺-Cu²⁺/Cu⁺) and PDA's electron modulation enhanced detection.
• The platform showed high reproducibility, anti-interference, and applicability to real samples (84.3%-118.8% recovery).

Conclusions:

• A generalizable approach for multifunctional bimetallic MOFs-based nanozymes was demonstrated.
• The developed platform enables integrated analytical systems with multi-mode signal outputs.
• This work advances environmental and biosensing applications through innovative nanozyme design.