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Related Concept Videos

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

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Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
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Chronic obstructive pulmonary disease is a common, preventable, and treatable respiratory disorder characterized by persistent symptoms and progressive airflow limitation. This limitation results from a combination of small-airway disease (obstructive bronchiolitis) and parenchymal destruction (emphysema), both driven by chronic inflammation from exposure to harmful particles or gases.The disease includes two main pathological entities: emphysema, marked by destruction of alveolar walls and...
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In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
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COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
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Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
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Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
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Methods for Detecting Cough and Airway Inflammation in Mice
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Acute and Chronic Cough in Children.

Douglas Kempthorne1, Yann-Fuu Kou2

  • 1Department of Otolaryngology-Head & Neck Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Otolaryngologic Clinics of North America
|May 5, 2026
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Summary

Pediatric cough, common in children, usually resolves quickly. Persistent cough beyond 4 weeks requires evaluation to prevent long-term lung issues, guided by specific pediatric cough guidelines.

Keywords:
Acute coughAsthmaChronic coughProtracted bacterial bronchitisUpper airway cough syndrome

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Area of Science:

  • Pediatrics
  • Pulmonology
  • Clinical Medicine

Background:

  • Cough is a prevalent symptom in pediatric populations.
  • Acute cough typically resolves within 4 weeks, often due to viral infections.
  • Chronic cough (lasting >4 weeks) necessitates thorough investigation to rule out underlying pathology.

Purpose of the Study:

  • To review evidence-based strategies for evaluating pediatric cough.
  • To outline diagnostic approaches for acute and chronic cough in children.
  • To highlight effective management and treatment options for pediatric cough.

Main Methods:

  • Literature review of pediatric cough guidelines and clinical studies.
  • Analysis of diagnostic algorithms for cough evaluation in children.
  • Synthesis of evidence on treatment modalities for pediatric cough.

Main Results:

  • Pediatric-specific guidelines provide a structured approach to cough diagnosis.
  • Early and accurate diagnosis is crucial for preventing chronic pulmonary complications.
  • Targeted treatments based on etiology improve patient outcomes.

Conclusions:

  • Implementing algorithmic evaluation aids in timely diagnosis of pediatric cough.
  • Adherence to evidence-based guidelines can mitigate long-term respiratory sequelae.
  • Comprehensive management strategies are essential for addressing pediatric cough effectively.