Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neurotransmitters01:31

Neurotransmitters

4.0K
Neurotransmitters are essential chemical messengers within the nervous system, facilitating the communication between neurons. These chemical messengers, varying in function and effect, are critical for sustaining various aspects of neurological health and emotional well-being.
4.0K
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

2.1K
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
2.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multimodal Conscious Analgesia with Oliceridine and Alfentanil Plus Local Anesthesia in Revisional Upper Eyelid Blepharoplasty: A Multicenter Randomized Clinical Trial.

Aesthetic plastic surgery·2026
Same author

Self-Powered Smart Textiles for Accelerated Wound Healing through Band Alignment in Piezoelectric Heterojunctions.

ACS nano·2026
Same author

Fe<sup>2+</sup>/O<sub>2</sub>-based advanced oxidation process coupled with air sparging/ circulation well for in-situ groundwater remediation: Synergistic technologies construction and feasibility assessment.

Journal of hazardous materials·2026
Same author

pH-responsive CDs-based nanoplatform for chemo-resistant esophageal cancer treatment via downregulation of HIF-1α related pathway.

Journal of nanobiotechnology·2026
Same author

Rosiglitazone alleviates Parkinson's disease phenotypes of Drosophila via dCTP-mediated inhibition of AGE-RAGE pathway.

Neuropharmacology·2026
Same author

Tertiary lymphoid structures (TLS): The mechanism hub and therapeutic target of neoadjuvant immunotherapy for hepatocellular carcinoma.

Critical reviews in oncology/hematology·2026
Same journal

The Ameliorative Effect of Spirulina platensis as Add-On Therapy to Risperidone on Valproic Acid-Induced Autism in Rat Pups: Implication of Oxidative Stress, Inflammatory, and ERK-1/2 Signaling Pathway.

Developmental neurobiology·2026
Same journal

From Behavioral and Sleep Disturbances to Genetic Diagnosis: Smith-Magenis Syndrome and the Importance of the Diagnostic Pathway.

Developmental neurobiology·2026
Same journal

Is There Any Difference in the Novel Serum Inflammatory Biomarkers of Adolescents With DMDD and Bipolar Disorder?

Developmental neurobiology·2026
Same journal

An Effective LRSF-DLNN-Based Autism Spectrum Disorder Prediction Using EEG and fMRI.

Developmental neurobiology·2026
Same journal

Disrupted Vestibular Nuclei Neuron Development in a Chick Model for Congenital Vestibular Disorders.

Developmental neurobiology·2026
Same journal

Association Analysis Between HEI-2020 Index and Maternal Pregnancy Behaviors on ADHD in Adolescent Populations: A NHANES Cross-Sectional Study.

Developmental neurobiology·2026
See all related articles

Related Experiment Video

Updated: May 7, 2026

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders
07:43

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

Published on: May 12, 2015

11.3K

Roles of POU3F2 in Brain Development and Neuropsychiatric Disorders.

Xueqin Liu1, Huihua Xu1, Yunhe Zhao1

  • 1School of Basic Medical Sciences, Shanxi Medical University, Taiyuan, China.

Developmental Neurobiology
|May 6, 2026
PubMed
Summary
This summary is machine-generated.

POU3F2 is crucial for brain development and linked to neuropsychiatric disorders. Understanding its role may lead to new treatments for neurological conditions.

Keywords:
POU3F2brain developmentneurodegenerative diseasesneuronal reprogrammingpsychiatric disorders

More Related Videos

Examination of Anatomical Features of Retinal Ganglion Cells Under N-methyl-D-aspartic Acid (NMDA)-induced Excitotoxicity
07:11

Examination of Anatomical Features of Retinal Ganglion Cells Under N-methyl-D-aspartic Acid (NMDA)-induced Excitotoxicity

Published on: September 19, 2025

1.0K
Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs
10:47

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs

Published on: March 2, 2018

9.3K

Related Experiment Videos

Last Updated: May 7, 2026

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders
07:43

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

Published on: May 12, 2015

11.3K
Examination of Anatomical Features of Retinal Ganglion Cells Under N-methyl-D-aspartic Acid (NMDA)-induced Excitotoxicity
07:11

Examination of Anatomical Features of Retinal Ganglion Cells Under N-methyl-D-aspartic Acid (NMDA)-induced Excitotoxicity

Published on: September 19, 2025

1.0K
Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs
10:47

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs

Published on: March 2, 2018

9.3K

Area of Science:

  • Neuroscience
  • Genetics
  • Developmental Biology

Background:

  • POU3F2 (Pit-Oct-Unc domain 2) is a transcription factor vital for central nervous system development.
  • POU3F2 deletion causes severe brain malformations and early mortality in mice.
  • Emerging evidence links POU3F2 dysfunction to various neuropsychiatric disorders.

Purpose of the Study:

  • To systematically review the multifaceted roles of POU3F2.
  • To analyze its involvement in brain development, neuropsychiatric disorders, and neuronal reprogramming.
  • To highlight POU3F2-targeted therapies for neurological conditions.

Main Methods:

  • Literature review and systematic analysis of POU3F2 functions.
  • Synthesis of data on POU3F2's role in brain development.
  • Compilation of evidence linking POU3F2 to neuropsychiatric disorders and neuronal reprogramming.

Main Results:

  • POU3F2 is essential for hypothalamus and neocortex development.
  • POU3F2 is implicated in Alzheimer's, Parkinson's, schizophrenia, and autism spectrum disorder.
  • POU3F2 facilitates somatic cell reprogramming into neuronal lineages.

Conclusions:

  • POU3F2 is a pivotal factor in brain development, disease pathogenesis, and neural cell reprogramming.
  • Further understanding of POU3F2's molecular mechanisms is key for novel therapeutic strategies.
  • Targeting POU3F2 offers potential for treating neuropsychiatric disorders.