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Updated: May 7, 2026

Mouse Model of Metabolic Dysfunction-Associated Steatotic Liver Disease with Fibrosis
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High Cardiometabolic Risk Burden Predicts Adverse Outcomes in Patients with MASLD-Related Hepatocellular Carcinoma

Yeonhong Do1, Young Hyeon Ahn2, Young Chang1

  • 1Department of Internal Medicine, Institute for Digestive Research, Digestive Disease Center, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Korea.

Gut and Liver
|May 6, 2026
PubMed
Summary

A higher number of cardiometabolic risk factors (CMRFs) in patients with metabolic dysfunction-associated steatotic liver disease (MASLD)-related liver cancer predicts worse survival. This cumulative metabolic burden is linked to larger tumors and elevated PIVKA-II levels.

Keywords:
Cardiometabolic risk factorsHDL cholesterolHepatocellular carcinomaHypertensionSurvival analysis

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