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Research Progress on Nanoformulations Based on Active Components from Traditional Chinese Medicine for MASLD
Zi-Xiu Gou1, Ning-Wei Li1, Jun-Yi Yao1
1Department of Gastroenterology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, People's Republic of China.
International Journal of Nanomedicine
|May 6, 2026
Summary
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing health concern. Nanotechnology enhances Traditional Chinese Medicine (TCM) compounds for better MASLD treatment, addressing limitations like poor solubility and bioavailability.
Area of Science:
- Hepatology
- Nanomedicine
- Pharmacology
Background:
- Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent chronic liver condition with limited treatment options.
- Traditional Chinese Medicine (TCM) offers multi-target therapeutic potential for MASLD.
- TCM compounds face challenges including poor solubility, low bioavailability, and lack of tissue specificity.
Purpose of the Study:
- To review and synthesize current research on nanotechnology-based Traditional Chinese Medicine (TCM) nanoformulations for Metabolic dysfunction-associated steatotic liver disease (MASLD).
- To classify MASLD-oriented TCM nanoformulations based on nanoplatform type and design features.
- To analyze the mechanism-related therapeutic actions of these nanoformulations against MASLD.
Main Methods:
- A structured literature search was conducted across four databases.
- 45 representative studies focusing on MASLD-related TCM nanoformulations were included.
- Studies were narratively synthesized, categorizing them by nanoplatform, design, and therapeutic mechanisms.
Main Results:
- Nanoformulations significantly improve the utilization and efficacy of TCM-derived active ingredients for MASLD.
- Key nanoplatform types and design features relevant to MASLD treatment were identified.
- The review highlights specific mechanisms through which TCM nanoformulations exert therapeutic effects in MASLD.
Conclusions:
- Nanotechnology offers a promising strategy to overcome the limitations of TCM compounds in MASLD management.
- MASLD-oriented TCM nanoformulations demonstrate potential for enhanced therapeutic efficacy and targeted delivery.
- Further research and clinical translation are needed to fully realize the potential of these nanoformulations.