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Complications Associated With Polycaprolactone (PCL) Use in Septorhinoplasty: A Systematic Review and Meta-Analysis.
Panutas Piyananthasomdee1, Minh P Hoang2, Kachorn Seresirikachorn1
1Department of Otolaryngology, Faculty of Medicine Chulalongkorn University Bangkok Thailand.
OTO Open
|May 6, 2026
Summary
Polycaprolactone (PCL) shows low complication rates in septorhinoplasty, with stiffness being the most common issue. Further research is needed to confirm its long-term safety and efficacy.
Area of Science:
- Plastic Surgery
- Biomaterials Science
Background:
- Septorhinoplasty aims to improve nasal function and aesthetics.
- Polycaprolactone (PCL) is a synthetic biodegradable polymer used as a graft material in reconstructive surgery.
- Complications associated with PCL use in septorhinoplasty require thorough evaluation.
Purpose of the Study:
- To systematically review and evaluate the complications associated with the use of polycaprolactone (PCL) in septorhinoplasty procedures.
- To identify the incidence of various complications, including deformity, stiffness, infection, and need for revision.
Main Methods:
- A comprehensive literature search was conducted across OVID EMBASE, OVID MEDLINE, SCOPUS, and PubMed.
- Studies reporting complications related to PCL in septorhinoplasty were included.
- Pooled mean proportions of complications were calculated, with subgroup analyses planned based on surgical factors.
Main Results:
- Analysis of 13 studies involving 1194 patients revealed generally low complication rates.
- Stiffness (0.72%) was the most reported complication, while others like deviation, skin complications, infection, and protrusion were below 0.03%.
- No statistically significant differences in complication rates were found across operation or graft types in subgroup analyses.
Conclusions:
- Polycaprolactone (PCL) demonstrates acceptable short- to mid-term safety for septorhinoplasty.
- Long-term data and comparative studies are necessary to fully establish the role of PCL in septorhinoplasty.
- While overall complication rates are low, stiffness remains a notable concern requiring further investigation.
