Thai Translation and Validation of Chronic Rhinosinusitis-Patient Reported Outcome (CRS-PRO)

Area of Science:

• Otolaryngology
• Medical Informatics
• Health Outcomes Research

Background:

• Chronic rhinosinusitis (CRS) significantly impacts patient quality of life.
• Patient-reported outcome measures are crucial for assessing CRS severity and treatment effectiveness.
• The Chronic Rhinosinusitis Patient-Reported Outcome (CRS-PRO) questionnaire was developed using current diagnostic criteria.

Purpose of the Study:

• To translate and validate the CRS-PRO questionnaire for use in the Thai population.
• To ensure the adapted instrument accurately reflects the experiences of Thai patients with CRS.
• To establish the psychometric properties of the Thai version of the CRS-PRO.

Main Methods:

• A three-phase translation process was employed, followed by validation at a tertiary hospital.
• Discriminant validity was assessed by comparing CRS patients with non-CRS controls.
• Concurrent validity was evaluated against the Thai SNOT-22, and reliability was determined using Cronbach's alpha and ICC.

Main Results:

• The Thai CRS-PRO was validated in 85 CRS patients and 40 controls.
• Significant differences in scores were observed between CRS patients and controls (p < 0.001).
• The questionnaire demonstrated strong concurrent validity (ρ = 0.82), high internal consistency (α = 0.89), and good test-retest reliability (ICC = 0.81).

Conclusions:

• The Thai-translated CRS-PRO is a valid and reliable instrument for assessing Thai CRS patients.
• The questionnaire shows excellent correlation with the Thai SNOT-22 and distinguishes well between patients and controls.
• Its brevity and efficiency make it suitable for both clinical practice and research settings.