Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Transcriptomic landscape of Gallbladder cancer reveals altered pathways related to cell cycle and Aurora kinase.

Scientific reports·2026

Same author

miRNA-mRNA network analysis reveals novel post-transcriptional regulators and therapeutic targets in coronary artery disease.

Journal of applied genetics·2026

Same author

Comprehensive transcriptomic analysis highlights immune and cell-cycle dysregulation in Diamond-Blackfan Anaemia.

Molecular genetics and genomics : MGG·2026

Same author

IGFBP3 repression driven by inflammation links air pollution to placental and developmental defects.

EMBO molecular medicine·2026

Same author

India's Twin Paradox: Abundant Resource, Absent Research.

Twin research and human genetics : the official journal of the International Society for Twin Studies·2026

Same author

In Silico Analysis of the Role of Estrogen Signaling in the Expression of Metabolic Genes in Breast Cancer.

Asian Pacific journal of cancer prevention : APJCP·2025

Same journal

Growth Model for Continuous Culture of a Hydrogen-Oxidizing Bacterium, Hydrogenophilus thermoluteolus Strain TH-1.

Biotechnology and bioengineering·2026

Same journal

Glycoengineered Recombinant Alpha1-Antitrypsin Results in Comparable In Vitro and In Vivo Activities to Human Plasma-Derived Protein.

Biotechnology and bioengineering·2026

Same journal

Minimizing Off-Target Effects of CRISPR-Cas9 With Optimized sgRNA: Evaluation of Efficiency and Specificity in the Tumor Protein 53 (TP53) Region.

Biotechnology and bioengineering·2026

Same journal

Metabolic Flux Analysis Reveals Cell Line-Specific Rewiring in CHO Cells Following TCA Cycle Intermediate Feeding for Bioprocess pH Control.

Biotechnology and bioengineering·2026

Same journal

Photohydrogenotrophic Cultivation of Purple Non-Sulfur Bacteria in an Open Bioreactor: Enhanced Selectivity Through Light Cycling and Ammonium Limitation.

Biotechnology and bioengineering·2026

Same journal

Translating Blue Light Stimulation From Batch to Perfusion: Process and Intracellular Metabolic Analysis.

Biotechnology and bioengineering·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 7, 2026

Author Spotlight: Developing a Unique Modular Microphysiological System to Mimic Human Barrier Tissue

Author Spotlight: Developing a Unique Modular Microphysiological System to Mimic Human Barrier Tissue

Published on: February 16, 2024

Microphysiological Systems: Transforming Biomedical and Clinical Research.

Om Saswat Sahoo¹, Avisha Tyagi¹, Aparna K Sharma²

¹Department of Biochemistry, All India Institute of Medical Sciences New Delhi, New Delhi, India.

Biotechnology and Bioengineering

|May 6, 2026

Summary

This summary is machine-generated.

Microphysiological systems (MPS) offer human-relevant models for drug development, overcoming limitations of traditional methods. These organ-on-chip technologies are advancing pharmaceutical research and safety assessment.

Keywords:

disease modeling drug development microfluidics microphysiological systems organ‐on‐a‐chip personalized medicine

More Related Videos

A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation

A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation

Published on: December 9, 2021

BioMEMS: Forging New Collaborations Between Biologists and Engineers

BioMEMS: Forging New Collaborations Between Biologists and Engineers

Published on: November 1, 2007

Related Experiment Videos

Last Updated: May 7, 2026

Author Spotlight: Developing a Unique Modular Microphysiological System to Mimic Human Barrier Tissue

Author Spotlight: Developing a Unique Modular Microphysiological System to Mimic Human Barrier Tissue

Published on: February 16, 2024

A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation

A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation

Published on: December 9, 2021

BioMEMS: Forging New Collaborations Between Biologists and Engineers

BioMEMS: Forging New Collaborations Between Biologists and Engineers

Published on: November 1, 2007

Area of Science:

Biomedical Engineering
Drug Development
Translational Science

Background:

The pharmaceutical industry faces significant drug development challenges due to the low predictive power of conventional preclinical models.
Microphysiological systems (MPS) are emerging as advanced, human-relevant alternatives to traditional in vitro and animal models.

Purpose of the Study:

To review the technological advancements, biological applications, and regulatory landscape of MPS in drug development.
To highlight the potential of MPS in addressing the translational bottleneck in pharmaceutical research.

Main Methods:

Integration of microfabrication, biomaterials, stem cell biology, microfluidics, and real-time sensing.
Development of organ-specific platforms, multi-organ systems, and body-on-chip models for pharmacokinetic and pharmacodynamic studies.

Main Results:

MPS platforms can recapitulate organ-level structure, function, and disease dynamics with high physiological fidelity.
Regulatory bodies like the FDA are increasingly recognizing MPS as a validated approach for drug development and safety assessment.

Conclusions:

MPS represent a transformative technology for improving the predictive accuracy of preclinical drug testing and accelerating development timelines.
Addressing challenges in cell sourcing, heterogeneity, scalability, and standardization is crucial for the widespread adoption of MPS.