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Related Concept Videos

Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
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Living cells constantly carry out various chemical reactions which are necessary for their proper functioning. These reactions are interlinked to one another via multiple pathways. The collection of these chemical reactions is known as metabolism.
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Related Experiment Video

Updated: May 8, 2026

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
14:56

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Published on: May 6, 2022

Income, diet, and cognitive function: observational analyses and candidate metabolomic pathways identified by

Xingguang Zhao1, Weijian Wu2, Qiaoxuan Zhang3

  • 1Department of Neurology, Institute of Neuroscience, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China; School of Public Health, Guangzhou Medical University, Guangzhou, China.

The Journal of Prevention of Alzheimer'S Disease
|May 6, 2026
PubMed
Summary

Higher household income is linked to better cognitive function, with cheese and coffee intake potentially mediating this effect through gut metabolites. Dietary interventions may help prevent cognitive decline in lower-income individuals.

Keywords:
Cognitive functionDementiaDietary patternsGut metabolitesMendelian randomizationSocioeconomic status

Related Experiment Videos

Last Updated: May 8, 2026

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
14:56

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Published on: May 6, 2022

Area of Science:

  • Neuroscience
  • Genetics
  • Metabolomics

Background:

  • Household income significantly impacts cognitive function.
  • Dietary patterns and gut microbiota metabolites may mediate this relationship.
  • Existing research highlights the need for integrated analyses.

Purpose of the Study:

  • To investigate the causal relationship between household income and cognitive performance.
  • To explore the mediating roles of dietary patterns and gut metabolites.
  • To assess the impact of income on cognitive trajectory over time.

Main Methods:

  • Utilized observational data from 13,457 UK Biobank participants with cognitive transitions.
  • Applied multistate Markov models for cognitive trajectory analysis.
  • Employed two-sample, two-step Mendelian randomization (MR) with GWAS data for causal inference and mediation analysis of 1400 gut metabolites.

Main Results:

  • Higher income correlated with reduced risk of cognitive deterioration over a median follow-up of 8.96 years.
  • MR confirmed a causal effect of income on cognitive performance (OR: 2.140, P < 0.001).
  • Cheese and coffee intake showed significant mediation, with cheese's effect linked to tryptophan/tyrosine and carnitine/ergothioneine metabolism.

Conclusions:

  • Confirmed a significant link between income and cognitive performance.
  • Identified cheese and dried fruit as potential mediators via amino acid and carnitine metabolism.
  • Suggests dietary pattern interventions could prevent income-related cognitive decline.