Related Experiment Video

Updated: May 8, 2026

Catheter-based Endovascular Angioplasty for Fibrosing Mediastinitis-associated Pulmonary Vein Stenosis
06:59

Catheter-based Endovascular Angioplasty for Fibrosing Mediastinitis-associated Pulmonary Vein Stenosis

Published on: August 26, 2025

Transcatheter Interventional Options in Pulmonary Vein Stenosis: When to Stent?

Heidi Van1, Christopher J Petit1, Oliver M Barry1

  • 1Division of Pediatric Cardiology, Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, NewYork-Presbyterian Hospital Morgan Stanley Children's Hospital, New York, NY, USA.

Seminars in Thoracic and Cardiovascular Surgery. Pediatric Cardiac Surgery Annual
|May 6, 2026
PubMed

Insights

Catheter interventions improve survival for infants with pulmonary vein stenosis (PVS). Early diagnosis, surveillance, and multidisciplinary care are key for better outcomes in this rare, aggressive condition.

Area of Science:

  • Pediatric Cardiology
  • Interventional Cardiology
  • Vascular Biology

Background:

  • Pulmonary vein stenosis (PVS) is a rare, aggressive pediatric condition with high mortality.
  • Characterized by neointimal proliferation and multivessel involvement, PVS historically has poor outcomes.

Purpose of the Study:

  • To review the role of catheter-based interventions in managing pediatric pulmonary vein stenosis.
  • To highlight the importance of a multidisciplinary approach and ongoing innovation.

Main Methods:

  • Review of current evidence on catheter-based interventions for PVS.
  • Discussion of balloon angioplasty, stenting (bare-metal and drug-eluting), and serial procedures.
  • Emphasis on early diagnosis, surveillance, and medical therapies.

Main Results:

  • Catheter interventions, including angioplasty and stenting, restore vessel patency in PVS.
  • Recurrent stenosis is common, necessitating frequent reintervention.
  • Reintervention, early diagnosis, and multidisciplinary care improve survival and quality of life.

Conclusions:

  • Transcatheter interventions are a cornerstone of modern multimodal treatment for pediatric PVS.
  • A multidisciplinary approach significantly improves survival and quality of life.
  • Continued innovation in device technology and biologic modulation is crucial for advancing outcomes.

Keywords:
congenital heart diseasepulmonary vein stenosistranscatheter interventions

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