Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

In Vitro Drug Dissolution: Alternative Methods01:17

In Vitro Drug Dissolution: Alternative Methods

Alternative drug dissolution methods include the rotating bottle, intrinsic dissolution test, peristalsis, and the Franz diffusion cell method. The rotating bottle method involves meticulously rotating tightly capped controlled-release beads in a temperature-controlled bath. Periodic decanting of samples allows for residue assay, followed by refilling with fresh medium and testing at various pH levels to emulate the gastrointestinal tract conditions.In contrast, the intrinsic dissolution test...
Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
Solvents01:12

Solvents

A solvent is a substance, most often a liquid, that can dissolve other substances. Here, the substance being dissolved is called a solute. When a solvent and a solute combine, they form a solution - a homogenous mixture of both the solvent and the solute. Water is a universal biological solvent. Its polar structure allows it to dissolve many other polar compounds. The ability of water to dissolve is governed by a balance between water molecules binding to each other and binding to the solute.
A...
Theories of Dissolution: Diffusion Layer Model01:15

Theories of Dissolution: Diffusion Layer Model

Dissolution, the process by which drug particles dissolve in a solvent, is explained by the diffusion layer model, a theoretical framework that simulates the absorption of oral drugs and allows us to analyze experimental data.
This process starts with a thin layer, saturated with the drug, forming at the interface between the solid and liquid. The solute then diffuses from this layer into the main solution. The Noyes-Whitney equation suggests that the rate of dissolution relies on the diffusion...
Clinically Relevant Drug Product Specifications: Methods of Establishment01:29

Clinically Relevant Drug Product Specifications: Methods of Establishment

Product specifications define the acceptable quality of a pharmaceutical product by ensuring identity, purity, potency, and strength. These specifications serve as benchmarks during development, manufacturing, and post-approval quality control. Clinically relevant specifications are particularly important because they directly relate to a drug's safety and efficacy in clinical use.Dissolution studies are critical biopharmaceutic tools that link in vitro behavior to in vivo performance. They...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immunological Profiling of Leukocyte Subset Proportions and Novel Blood Biomarkers in the Acute Phase of Ocular Sarcoidosis and Vogt-Koyanagi-Harada Disease: An Exploratory Pilot Study.

International journal of molecular sciences·2026
Same author

Cyclosporine Resolved Late Graft Failure After Autologous Transplantation for Neuroblastoma by Promoting CD4 T-Cell Recovery.

Pediatric blood & cancer·2026
Same author

Enhancing the Physicochemical Properties of Trimethoprim through Complexation with Sulfathiazole.

ACS omega·2026
Same author

Analysis of intracellular organelles in neurons differentiated from iPSCs of Chédiak-Higashi syndrome patients.

Pediatrics international : official journal of the Japan Pediatric Society·2026
Same author

Crystal Structure and Physical Properties of Loxoprofen Sodium Dihydrate.

Chemical & pharmaceutical bulletin·2025
Same author

Re-examination of the juxta-oral organ in domestic chicken (Gallus gallus domesticus) using immunohistochemistry and micro-computer tomography techniques.

Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft·2025

Related Experiment Video

Updated: May 8, 2026

Preparation of Binary and Ternary Deep Eutectic Systems
06:15

Preparation of Binary and Ternary Deep Eutectic Systems

Published on: October 31, 2019

Deep Eutectic Solvents in Active Pharmaceutical Ingredient Development.

Masataka Ito1

  • 1Faculty of Pharmaceutical Sciences, Toho University.

Chemical & Pharmaceutical Bulletin
|May 6, 2026
PubMed
Summary
This summary is machine-generated.

Deep eutectic solvents (DESs) offer a sustainable solution for pharmaceutical development by significantly enhancing the solubility of poorly soluble active pharmaceutical ingredients (APIs). These versatile solvents also facilitate the creation of novel drug formulations like salts and cocrystals.

Keywords:
active pharmaceutical ingredientcocrystalcrystallizationdeep eutectic solvent

More Related Videos

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
08:18

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
05:08

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

Published on: September 20, 2017

Related Experiment Videos

Last Updated: May 8, 2026

Preparation of Binary and Ternary Deep Eutectic Systems
06:15

Preparation of Binary and Ternary Deep Eutectic Systems

Published on: October 31, 2019

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
08:18

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
05:08

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

Published on: September 20, 2017

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science
  • Green Chemistry

Background:

  • Deep eutectic solvents (DESs), formed by mixing solid hydrogen bond donors and acceptors, exhibit a significant melting point depression.
  • Since their introduction in 2003, DESs have gained traction due to their cost-effectiveness, adjustable properties, and environmental benefits.
  • Their application in pharmaceutical sciences is expanding as alternative solvents and functional media for active pharmaceutical ingredient (API) development.

Purpose of the Study:

  • To review recent advancements in the utilization of DESs within pharmaceutical research.
  • To highlight the role of DESs in improving the solubility of poorly water-soluble APIs.
  • To explore the formation of multicomponent crystals using DESs as both media and coformer sources.

Main Methods:

  • Review of literature on the application of DESs in pharmaceutical research.
  • Analysis of DESs' impact on API solubility compared to traditional solvents like water.
  • Investigation of DESs as crystallization media for preparing salts and cocrystals.

Main Results:

  • DESs demonstrate a substantial increase in API solubility, often by several orders of magnitude compared to water.
  • DESs enable the preparation of salts and cocrystals without the need for conventional organic solvents.
  • The study discusses the influence of DES composition, viscosity, and water content on solubility, crystallization, and processability.

Conclusions:

  • DESs present a promising and sustainable platform for innovative API development.
  • Challenges such as high viscosity and product separation are acknowledged, with proposed mitigation strategies including dilution, additives, and solvent recycling.
  • DESs offer a versatile approach for enhancing drug solubility and creating novel solid forms.