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Sprayable Intranasal Powder Formulation of Ionic Liquid-Associated Mesoporous Silica.
Naoto Suzuki1, Keita Fukushima1, Chihiro Kamiya1
1Laboratory of Pharmaceutics, School of Pharmacy, Nihon University.
Chemical & Pharmaceutical Bulletin
|May 6, 2026
Summary
This study developed a novel intranasal powder formulation using ionic liquids (ILs) encapsulated in mesoporous silica (MPS). This overcomes IL viscosity issues, improving nasal drug delivery device performance.
Area of Science:
- Pharmaceutical Science
- Materials Science
- Drug Delivery
Background:
- Ionic liquids (ILs) enhance nasal drug absorption but suffer from high viscosity, hindering intranasal administration.
- Existing intranasal delivery methods face challenges with viscous IL formulations.
Purpose of the Study:
- To develop a stable, powder-based ionic liquid formulation for improved intranasal administration.
- To overcome the viscosity and sprayability limitations of ionic liquids for nasal drug delivery.
Main Methods:
- Ionic liquid (choline and L-malic acid) loaded into mesoporous silica (MPS) pores.
- Characterization using IR spectroscopy, surface area analysis, and SEM.
- Evaluation of powder flowability and spray characteristics using an intranasal powder device.
Main Results:
- Successful encapsulation of ILs within MPS pores demonstrated by IR spectroscopy and SEM.
- Optimized MPS:IL ratio (1:0.4) achieved minimal surface residue.
- IL-MPS powders exhibited superior flowability and spray characteristics compared to lactose hydrate.
Conclusions:
- The developed IL-MPS powder formulation effectively addresses viscosity and sprayability challenges for intranasal delivery.
- This formulation shows promise as a viable option for enhancing nasal drug absorption via intranasal devices.
