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Related Experiment Video

Updated: May 8, 2026

Acute Mouse Brain Slicing to Investigate Spontaneous Hippocampal Network Activity

Acute Mouse Brain Slicing to Investigate Spontaneous Hippocampal Network Activity

Published on: August 28, 2020

Human hippocampal ripples coordinate planning sequences and compositional representations in neocortex.

Li He^1,2,3, Xiongfei Wang⁴, Jinbo Zhang^1,2,3

¹State Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.

Nature Neuroscience

|May 6, 2026

Summary

The human brain uses hippocampal ripples and replay to update medial prefrontal cortex (mPFC) representations for flexible planning. This mechanism helps combine familiar elements into novel solutions for complex problems.

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Last Updated: May 8, 2026

Acute Mouse Brain Slicing to Investigate Spontaneous Hippocampal Network Activity

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Horizontal Hippocampal Slices of the Mouse Brain

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Published on: September 22, 2020

Area of Science:

Neuroscience
Cognitive Science

Background:

The human brain flexibly plans by recombining elements, involving the hippocampus and medial prefrontal cortex (mPFC).
Neuronal mechanisms of hippocampus-mPFC interaction in flexible planning are not fully understood.

Purpose of the Study:

To investigate the neuronal mechanisms of hippocampus-mPFC interaction during complex inference tasks.
To elucidate how the brain dynamically updates representations for planning and problem-solving.

Main Methods:

High-resolution intracranial electroencephalography (iEEG) recorded simultaneously from hippocampus and mPFC in 28 epilepsy patients.
Participants performed two novel inference tasks involving compositional structures (LEGO-like).

Main Results:

Hippocampal ripples dynamically updated mPFC representations, encoding inferred solutions as compositional structures.
Neuronal replay during ripples reorganized elements into sequences, facilitating planning.
Replay strength correlated with mPFC activity and predicted behavioral efficiency.

Conclusions:

Hippocampal ripples and replay are crucial for online, dynamic updates of cortical representations.
This mechanism supports flexible planning and inference by enabling the recombination of elements into novel configurations.