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Updated: May 8, 2026

Novel Production Protocol for Small-scale Manufacture of Probiotic Fermented Foods

Novel Production Protocol for Small-scale Manufacture of Probiotic Fermented Foods

Published on: September 10, 2016

Probiotics: From natural to artificial.

Li-Hua Liu¹, Xianhong Zhang², Ying Huang³

¹Guangdong Provincial Key Laboratory of Marine Biotechnology, Guangdong Provincial Key Laboratory of Marine Disaster Prediction and Prevention, STU-UNIVPM Joint Algal Research Center, College of Science, Shantou University, Shantou 515063, PR China; Bio-Fermentation Research Center, Xiamen Yuanzhidao Biotechnology Co., Ltd., EYOSON Group Co., Ltd., Xiamen 361028, PR China.

Biotechnology Advances

|May 7, 2026

Summary

This summary is machine-generated.

Artificial probiotics offer enhanced health benefits beyond natural strains by overcoming limitations like poor specificity and stress tolerance. This review details technologies for their development and diverse applications, paving the way for next-generation personalized probiotics.

Keywords:

Artificial intelligence Directed evolution Genetic engineering Personalization Probiotics Safety assessment

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Area of Science:

Microbiology
Synthetic Biology
Biotechnology

Background:

Probiotics confer health benefits by maintaining gut homeostasis and producing metabolites.
Natural probiotics have limitations in functional specificity, stress tolerance, and performance.
Advances in multi-omics and synthetic biology enable rational design of artificial probiotics.

Purpose of the Study:

To systematically review core technologies for developing high-performance artificial probiotics.
To summarize the diverse applications of artificial probiotics.
To discuss challenges and future directions in artificial probiotic development.

Main Methods:

Review of core technologies including artificial intelligence (AI), high-throughput screening (HTS), directed evolution, genetic engineering, and gene editing.
Systematic summary of applications in gut-organ axis regulation, fermentation, disease treatment, drug delivery, and bioremediation.
Discussion of challenges in biosafety, regulation, adaptability, and dosage.

Main Results:

Core technologies like AI, HTS, directed evolution, and genetic engineering are crucial for artificial probiotic development.
Artificial probiotics have wide-ranging applications, including therapeutic and environmental uses.
Key challenges include biosafety, regulatory hurdles, in vivo performance, and dosage control.

Conclusions:

Artificial probiotics represent a significant advancement over natural strains, offering improved performance and specificity.
The development of artificial probiotics requires a multidisciplinary approach, integrating various cutting-edge technologies.
Future research should focus on personalized probiotics to optimize clinical translation and industrial application.