Related Experiment Video
Updated: May 8, 2026

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice
Published on: October 10, 2025
Prevalence of tuberculosis infection among pregnant women: a systematic review protocol
Prisana Mandeville1, Jan M Nick1,2, Fayette Truax1
1School of Nursing, Loma Linda University, Loma Linda, CA, USA.
Objective:
This systematic review will investigate the global pooled prevalence of tuberculosis (TB) infection among pregnant women.
Introduction:
TB infection affects 25% of the global population and poses a significant public health challenge, particularly among pregnant women who are at higher risk of progressing to TB disease.
Eligibility Criteria:
Studies will include pregnant women with TB infection, as identified by a tuberculin skin test or interferon-gamma release assay, irrespective of coexisting immunocompromizing conditions. Eligible sources will comprise cross-sectional and cohort studies, and surveillance reports from any geographic setting. Studies focusing on TB disease, lacking prevalence data, or presenting mixed data that cannot be disaggregated for the target population will be excluded.
Methods:
This proposed systematic review will follow the PERSyst group guidance for systematic reviews of prevalence. A 3-step search strategy will be applied, covering 2014 to the present, with no language restrictions. Databases include CINAHL (EBSCOhost), Embase, Google Scholar, PubMed, LILACS, and Web of Science Core Collection, while sources of gray literature will be international and professional organizations' websites. Study selection will follow a 3-step process, including critical appraisal for methodological quality. Standardized data extraction tools will be used. Two reviewers will independently handle each step, with conflicts resolved by consensus or with a third reviewer. Narrative synthesis will be conducted and, where feasible, a random-effects meta-analysis will be performed to estimate pooled TB infection prevalence with 95% CIs. Heterogeneity will be assessed using the I 2 statistic, acknowledging that substantial heterogeneity is common in prevalence meta-analyses.
Review Registration:
PROSPERO CRD420251026181.
Related Concept Videos
Pulmonary Tuberculosis V
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Pulmonary Tuberculosis IV
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Pulmonary Tuberculosis I
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Pulmonary Tuberculosis III
The first classification is based on the development of the disease, and it includes the following categories:
Development of the Oral Microbiota
Pulmonary Tuberculosis II
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
