Evaluation of AI-assisted chart review for acute myocardial infarction and cardiogenic shock
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Updated: May 8, 2026

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Published on: June 12, 2021
Karoline Korsholm Jeppesen1,2, Rasmus Bo Lindhardt2,3, Anika Klein4
1Department of Cardiology, Odense University Hospital.
Insights
AI-assisted chart review significantly speeds up patient screening for acute myocardial infarction complicated by cardiogenic shock (AMICS) registries. This artificial intelligence tool maintains diagnostic accuracy while reducing manual review time.
Area of Science:
- Cardiology
- Medical Informatics
- Artificial Intelligence
Background:
- The Danish RETROSHOCK registry tracks patients with acute myocardial infarction complicated by cardiogenic shock (AMICS).
- Manual chart review for registry updates is time-consuming.
- Funding for the RETROSHOCK database is provided by Johnson and Johnson Med Tech and the Novo Nordic Foundation.
Purpose of the Study:
- To evaluate the efficiency and accuracy of an AI-assisted chart review tool for AMICS patient identification.
- To compare the time required for AI-assisted versus manual chart review.
Main Methods:
- A natural language processing AI tool was developed to identify AMICS-related keywords in electronic medical records.
- Electronic medical records from Odense University Hospital (2018-2022) were screened.
- AI-assisted screening was compared to manual chart review for time efficiency and diagnostic accuracy (Cohen's kappa).
Main Results:
- AI-assisted review achieved perfect agreement with manual review (Cohen's kappa = 1).
- Median inclusion time was reduced from 2:20 minutes (manual) to 1:16 minutes (AI-assisted) (p < 0.001).
- Median exclusion time decreased from 2:45 minutes (manual) to 0:59 minutes (AI-assisted) (p < 0.001).
Conclusions:
- AI-assisted chart review significantly reduces screening time for AMICS patient registries.
- The AI tool maintains high diagnostic accuracy.
- This technology offers a more efficient method for updating clinical registries.
Introduction:
The Danish RETROSHOCK registry has provided valuable insights into patients with acute myocardial infarction complicated by cardiogenic shock (AMICS) and their clinical trajectories. However, continuously updating the registry through manual chart review is time-consuming.
Methods:
Electronic medical records were retrieved from patients admitted to Odense University Hospital from 2018 to 2022, assigned an ICD-10 code suggestive of AMICS. A random sample of 100 consecutive patients was selected for testing the AI-assisted chart review. The AI tool was a natural language processing model identifying AMICS-related keywords. Electronic medical records were initially screened using AI-assisted chart review, with time recorded until AMICS diagnosis or exclusion due to an alternative diagnosis. One week later, a manual chart review was performed. AI-assisted and manual screening times were compared using the Wilcoxon signed-rank test.
Results:
AI-assisted chart review identified the same 26 AMICS patients as manual review (Cohen's kappa = 1). Median manual inclusion time was 2:20 minutes, compared with 1:16 minutes with AI-assisted chart review (p less-than 0.001). Median manual exclusion time was 2:45 minutes, and AI-assisted exclusion was 0:59 minutes (p less-than 0.001).
Conclusions:
AI-assisted chart review significantly reduced screening time for including AMICS patients in the RETROSHOCK registry and excluding non-eligible patients, while preserving diagnostic accuracy.
Funding:
The RETROSHOCK database is supported by Johnson and Johnson Med Tech and the Novo Nordic Foundation.
Trial Registration:
Not relevant.
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