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Updated: May 8, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
08:43

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives

Published on: January 19, 2016

Highly Regioselective Trifluoromethylation of Unprotected Phenols and Anilines Enabled by an Engineered P450

Jie Chen1,2,3, Fuquan Yao1, Qian Wang1,2

  • 1Key Laboratory of Photoelectric Conversion and Utilization of Solar Energy, Qingdao New Energy Shandong Laboratory, CAS Key Laboratory of Biofuels, Shandong Provincial Key Laboratory of Synthetic Biology, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, China.

Angewandte Chemie (International Ed. in English)
|May 7, 2026
PubMed

Keywords:
anilinescytochrome P450 enzymesenzyme engineeringphenolstrifluoromethylation

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