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Different approaches of SARC-tools for Sarcopenia Screening in chronic obstructive pulmonary disease: A
Alicia S Hartmann1, João G Brum1, Thiago G Barbosa-Silva2
1Federal University of Health Sciences of Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil.
Background:
We aimed to assess the concurrent and predictive validity of different screening tools for sarcopenia in outpatients with chronic obstructive pulmonary disease.
Methods:
Cross-sectional study with 124 community-dwelling adults with chronic obstructive pulmonary disease (67.8 ± 8.4 years, 57.6% female). SARC-F, SARC-CalF, and SARC-CalFBMI-CC were applied; sarcopenia was diagnosed and considered as reference to test the concurrent validity. The outcomes evaluated to test the predictive validity included dyspnea severity, stage of disease, quality of life, the 6-min walk test, and the prognosis index.
Results:
SARC-CalFBMI-CC presented the highest sensitivity (79.5% vs 43.2% vs 20.5%), and negative predictive value (78.6% vs 68.8% vs 66.3%) compared to SARC-CalF and SARC-F, respectively. Patients with sarcopenia risk by SARC-CalFBMI-CC were 3.37 times (95% CI 1.18; 9.63) more likely to walk less than 350 m, 5.31 times (95% CI 2.01; 14.04) more likely to have poorer prognosis, 4.05 times (95% CI 1.55; 10.61) more likely to experience greater shortness of breath, and 6.4 times (95% CI 1.94; 21.13) more likely to have diminished quality of life. Risk of sarcopenia identified by SARC-F (advanced stage of disease, poor prognosis and quality of life) and SARC-Calf (advanced stage of disease, poor prognosis, and reduced functional capacity) was associated with a lower number of outcomes.
Conclusions:
SARC-CalFBMI-CC demonstrated the highest accuracy to identify sarcopenia. Patients with sarcopenia risk by SARC-CalFBMI-CC were more likely to present worse outcomes compared to those identified by SARC-F or SARC-Calf, suggesting the use of SARC-CalFBMI-CC for these patients.
