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Evaluation of the effect of long-term pulsed laser irradiation on cochlear function in Mongolian gerbils (Meriones
Yuta Tamai1,2,3, Yuta Kuroki1, Aya Okamoto1
1Neuroethology and Bioengineering, Graduate School of Life and Medical Sciences, Doshisha University, Kyotanabe, Kyoto, Japan.
Abstract:
This study evaluated the effects of infrared laser exposure on cochlear function in Mongolian gerbils. A 6.6-W/cm2 laser induced a stable cochlear response for 870 min, whereas higher irradiation levels resulted in a progressive and significant decline in response. The auditory-evoked compound action potential recorded before and after prolonged laser irradiation revealed that laser irradiation at 105.6 W/cm2 caused a prominent reduction in compound action potential across several frequencies, with the largest reduction occurring near the frequency corresponding to the irradiation site. These results demonstrate that laser irradiation at 6.6 W/cm2 or below can elicit a stable cochlear response, and suggest that prolonged laser irradiation potentially causes frequency-specific damage around the stimulated site.
