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Related Experiment Video

Updated: May 8, 2026

Revealing the Ferroptotic Phenotype of Medulloblastoma
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Revealing the Ferroptotic Phenotype of Medulloblastoma

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Selenized Probiotic L. brevis 23017 Alleviates Colitis by Modulating the Nrf2-GPX4 Axis to Inhibit Ferroptosis.

Yuxin Zhuang1, Qiuju Liu1, Fangfei Shi1

  • 1College of Veterinary Medicine, Northeast Agricultural University, No.600 Changjiang Road, Xiangfang District, Harbin, 150030, China.

Biological Trace Element Research
|May 7, 2026
PubMed
Summary

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Novel selenized probiotics and selenium nanoparticles effectively treat experimental colitis by reducing inflammation and oxidative stress. These therapies inhibit ferroptosis via the Nrf2-GPX4-HO-1 pathway, offering a promising approach for ulcerative colitis treatment.

Area of Science:

  • Gastroenterology and Hepatology
  • Nanomedicine
  • Microbiology

Background:

  • Ulcerative colitis (UC), a major form of inflammatory bowel disease (IBD), is increasing globally.
  • Current treatments for UC have limitations, necessitating novel therapeutic strategies.
  • Understanding the mechanisms of UC pathogenesis, including cell death pathways, is crucial for developing effective interventions.

Purpose of the Study:

  • To evaluate the therapeutic potential of selenized probiotic Lactobacillus brevis 23017 (Se-Lb23017) and biogenic selenium nanoparticles (SeNPs) in a dextran sodium sulfate (DSS)-induced colitis model.
  • To investigate the underlying mechanisms, focusing on ferroptosis inhibition and the Nrf2-GPX4-HO-1 signaling pathway.
  • To determine the optimal conditions for preparing Se-Lb23017.

Main Methods:

Keywords:
L. brevis 23017Antioxidant pathwayFerroptosisSelenium nanoparticlesUlcerative colitis

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Last Updated: May 8, 2026

Revealing the Ferroptotic Phenotype of Medulloblastoma
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  • Preparation of Se-Lb23017 using Na2SeO3, with 80 µg/mL identified as optimal.
  • Characterization of Se-Lb23017 and SeNPs using scanning electron microscopy (SEM).
  • In vivo assessment in a DSS-induced murine colitis model, evaluating disease activity index (DAI), weight loss, tissue damage, and colon length.
  • In vitro analysis of pro-inflammatory (TNF-α, IL-1β, IL-6) and anti-inflammatory (IL-10) cytokine expression.
  • Investigation of oxidative stress markers and the Nrf2-GPX4-HO-1 pathway activation.

Main Results:

  • Se-Lb23017 and SeNPs administration significantly ameliorated colitis symptoms, including reduced DAI, weight loss, and colon damage.
  • Both treatments suppressed pro-inflammatory cytokines and increased IL-10 levels in vitro.
  • Mechanistic studies revealed reduced oxidative stress and ferroptosis suppression through activation of the Nrf2-GPX4-HO-1 axis.
  • Lipid peroxidation levels were decreased, indicating ferroptosis inhibition.

Conclusions:

  • Se-Lb23017 and SeNPs demonstrate significant therapeutic efficacy in experimental colitis.
  • The protective effects are attributed to synergistic anti-inflammatory and antioxidant actions.
  • These agents provide cytoprotection by inhibiting ferroptosis via Nrf2-dependent pathway activation.
  • Selenized probiotics represent a promising therapeutic avenue for ulcerative colitis by targeting novel cell death modalities.