Related Experiment Video
Updated: May 9, 2026
An Ex Vivo Porcine Model for Hydrodynamic Testing of Experimental Aortic Valve Procedures and Novel Medical Devices
Published on: August 25, 2023
Simulations predict improved valve performance without direct leaflet intervention after neonatal truncus arteriosus
Karoline-Marie Bornemann1, Perry S Choi2, Jay Huber3
1Division of Pediatric Cardiology, Department of Pediatrics, Stanford University, Stanford, Calif; Maternal & Child Health Research Institute, Stanford University, Stanford, Calif.
Objectives:
Truncus arteriosus (TA) is a rare and severe congenital heart disease. Quadricuspid valve morphology occurs in 25% of patients with TA and is associated with regurgitation and increased risk of reoperation. It remains unclear how sudden hemodynamic changes after TA repair alter valve performance. This study simulated pre- and postoperative conditions investigating valve performance without leaflet intervention. We hypothesized that valve performance can be predicted in silico, matching in vivo imaging and identifying mechanisms by which postoperative hemodynamics will reduce valve regurgitation.
Methods:
Pre- and postoperative computed tomography images of a neonate with a quadricuspid valve were segmented. Free edge length and geometric height from the patient's echocardiogram were used for valve modeling. Fluid-structure interaction simulations of the coupled dynamics of the valve and blood were performed. Boundary conditions were tuned to match patient-specific clinical values, including the pulmonary-to-systemic flow ratio.
Results:
The preoperative simulation confirmed mild valve regurgitation observed in vivo. The combination of geometrically complex vessels and heterogeneous in- and outflow of the valve resulted in asymmetric valve opening and closing. Poor central leaflet coaptation led to a central regurgitant jet directed toward the septum. Altered postoperative hemodynamic conditions improved coaptation and eliminated regurgitation in silico, matching observed in vivo valve performance.
Conclusions:
This modeling approach reproduced in vivo valve performance and identified mechanisms improving postoperative coaptation. TA repair led to elimination of regurgitation via enhanced central coaptation through favorable fluid-valve interaction. Thus, altered postoperative hemodynamics after TA repair may improve valve performance without leaflet intervention.